Otsuka Pharmaceutical Company, Limited

Yasuo Nakayama

Wasei Miyazaki

Yoshikatsu Hirai

Masanao Shinohara

Yuji Sugahara

Osamu Sato

Tadao Sato

Setsuyoshi Uetsuki

Tsuneo Sato

Stabilized il-1.alpha. medicinal composition

The present invention provides a monoclonal antibody characterized in that the antibody has specific reactivity on human IL-1.beta., and a process for producing the antibody. The invention also provides a method for detection of biologically active human IL-1.beta..

Monoclonal antibody specific for human interleukin-1.beta. and method

This invention provides a urokinase complex adsorbable by fibrin characterized in that it comprises heavy chain of high molecular weight urokinase as coupled with heavy chain of plasmin by one or more S-S bonds and a process for preparing the same.

Urokinase-plasmin complex adsorbable by fibrin and process for preparing

This invention provides a process for preparing a fibrin-adsorable protein-urokinase complex characterized by reacting a protein adsorbable by fibrin with urokinase in the presence of a protein coupling reagent represented by the formula ##STR1## wherein R is phenylene or cycloalkylene, A is lower alkylene, B is lower alkylene which may optionally be substituted by lower alkylthio or phenyl-lower alkylthio, and l, m and n are each 0 or 1 provided that l, m and n are not 0 at the same time. The complex is useful as a thrombolytic agent.

Process for preparing urokinase complex

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Tokushima, Japan

Yasuo Nakayama