Takeda Chemical Industries, Inc.

Eisai R&d Management Co., Ltd.

Other

Iwatsubo, Takeshi

Yasuo Nagai

Kaneyoshi Kato

Tadafumi Hashimoto

Takeshi Iwatsubo

Koichi Kato

Yoshihiro Sugiura

Shigenori Ohkawa

Jun Terauchi

A novel human collagen-like protein CLAC occurring in brain amyloid and its precursor CLAC-P; genes encoding the same; cDNA of mouse CLAC-P and its deduced amino acid sequence; antibodies specific to these proteins; and methods of diagnosing treating and preventing Alzheimer's disease by using the same.

Collagen-like protein CLAC, a precursor thereof, and genes encoding the same

Collagen-like protein CLAC, precursor thereof and genes encoding the same

Quinone compound, its production and use as antioxidant

The compound ##STR1## wherein ring A represents a benzene ring;

Condensed heterocyclic compounds, their production and use

The compound ##STR1## wherein ring A represents a benzene ring; Ar represents an aromatic group; R.sup.1 and R.sup.2 independently represent hydrogen, acyl or hydrocarbon group or R.sup.1 and R.sup.2 taken together with the adjacent nitrogen atom represent a nitrogen-containing heterocyclic group; m represents an integer of 1 to 6; n represents an integer of 2 to 3; ----- represents a single bond or a double bond; X stands for --O-- or --NR.sup.3 -- in which R.sup.3 represents hydrogen, acyl or hydrocarbon group where ----- is a single bond or .dbd.N-- where ----- is a double bond has excellent GnRH receptor antagonizing activity, calcium antagonizing and monoamine-uptake inhibiting activities and and value as a prophylactic/therapeutic drug for sex hormone-dependent diseases and for central nervous system diseases.

A spiro compound represented by the formula: ##STR1## wherein ring A represents an optionally substituted aromatic ring; T represents an optionally substituted hydrogen atom or an optionally substituted hydrocarbon group; X represents --CH.sub.2 --, --CO-- or --CH(OH)--; D represents --CH.sub.2 --, --O-- or --NR-- wherein R is a hydrogen atom or an optionally substituted hydrocarbon group and m, e and f independently represent an integer from 1 to 3, or a salt thereof. The spiro compound inhibits monoamine uptake, monoamine oxidase B and/or Ca ion uptake, and is a prophylactic and therapeutic drug for a central nervous diseases.

Spiro[naphthalene-2(1H),2'-piperidine] and their use

Growing community of inventors

Osaka, Japan

Yasuo Nagai