Ajinomoto Co., Ltd.

Ajinomoto Co., Inc., Patent & Licensing Department

Yasuo Irie

Naohiko Yasuda

Hiroshi Shiragami

Michito Sumikawa

Kenzo Yokozeki

Hideyuki Shirae

Satoji Takahashi

Yoshihito Koguchi

Toshiya Tanabe

Masaru Otani

Fusayoshi Kakizaki

Takao Ohgane

Chieko Ishijima

Eiji Nakanishi

Hisao Iwagami

Katsunori Kobayashi

Hideomi Saito

A process for converting uridines to 2&prime;,3&prime;-dideoxy-2&prime;,3&prime;-didehydrouridines by reacting acetic anhydride with a 2&prime;,3&prime;-0-alkoxymethylideneuridine intermediate.

Process for producing and purifying 2&prime;,3&prime;-dideoxynucleosides, and process for producing 2&prime;,3&prime;-dideoxy-2&prime;,3&prime;-didehydronucleosides

Stable crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine may be produced by treating this compound with a solvent at a temperature of at least 10.degree. C. and forming crystals in the solvent at a temperature of at least 10.degree. C. For example, crystals may be formed by crystallization out of solution, or may be formed from solid particles of the compound suspended in a solvent. Crystals formed in this way have different melting point, infra red spectrum and X-ray diffraction patterns from previously known forms of the compound and have enhanced processability, eg. stability to grinding.

Crystals of N-(trans-4-isopropylcyclohexycarbonyl)-D-phenylalanine and

Stable crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine may be produced by treating this compound with a solvent at a temperature of at least 10.degree. C. and forming crystals in the solvent at a temperature of at least 10.degree. C. For example, crystals may be formed by crystallization out of solution, or may be formed from solid particles of the compound suspended in a solvent. Crystals formed in this way have different melting point, infra red spectrum and X-ray diffraction patterns from previously known forms of the compound and have enhanced processability, e.g., stability to grinding.

Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and

A method of producing dideoxyinosine involving contacting as a substrate 2',3'-dideoxyadenosine with a microorganism which is capable of converting the substrate into 2',3'-dideoxyinosine.

Method of producing 2',3'-dideoxyinosine

A biological process for producing a 2',3'-dideoxynucleoside from 2',3'-dideoxyuridine is disclosed. the 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin adsorbent.

Process for purifying 2',3'-dideoxynucleosides

A biological process for producing a 2',3'-dideoxyncleoside from 2',3'-dideoxyuridine is disclosed. The 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin adsorbent.

Process for producing and purifying 2',3'-dideoxynucleosides, and

A compound which is: ##STR1## wherein R may be 1 to 5 H, Cl, Br, F, C.sub.1 -C.sub.4 straight chain or branched alkyl, OH, or CF.sub.3.

Aromatic sulfonic acid salts of a proline derivative

A method of preparing sodium salts of an imidazoledicarboxylic acid derivative of a substituted cephalosporin represented by the general formula of ##STR1## where X is a radical selected from the group consisting of hydrogen, halogen, hydroxyl, alkyl, aryl, aralkyl, alkoxy, aryloxy, aralkyloxy, mercapto, alkylthio, arylthio, aralkylthio, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, alkylsulfinyl, arylsulfinyl, aralkylsulfinyl, amino, mono- or dialkylamino, mono- or diarylamino, mono- or diaralkylamino, acylamino, sulfonic acid, nitro or heterocyclic group;

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Kawasaki, Japan

Yasuo Irie