Ss Pharmaceutical Co., Ltd.

Ssp Co. Ltd

Hisamitsu Pharmaceutical Company, Inc.

Yasuo Ikeda

Shuichi Kasai

Akira Iwasa

Katsumi Imamori

Hirohisa Okuyama

Shigenori Otsuka

Satoru Enomoto

Minoru Okada

Kazuya Ishida

Kenji Ono

Toshiaki Kurazumi

Syuichi Kasai

Kenji Ishigaki

Koji Nashimoto

Yoshiaki Hanaoka

Shigenori Ohtsuka

A microorganism staining agent characterized in that an alkali substance and a diazo dye or xanthene dye are contained therein; and a method of detecting microorganisms with the use of the agent. There are provided a microorganism staining agent which resolves the problem of pretreatment posed by the conventional direct speculum method, being capable of staining microorganisms in shorter time; and a method of detecting microorganisms with the use of the agent.

Microorganism staining agent and use thereof

An orally administrable uncompressed rapidly dissolving molded dosage form comprises a drug and either one or more saccharides or one saccharide and polyvinylpyrrolidone. Saccarides are chosen and used in proportion based on their solubilities. Methods for producing uncompressed rapidly dissolving solid preparations comprise mixing a drug and carriers according to the present invention and charging the mixture in a mold. Rapidly dissolving oral dosage forms facilitate administration of drugs to patients having a difficulty in swallowing such as children and the elderly.

Quickly soluble solid preparations

A hydrophilic adhesive mass contains 0.05 to 10 wt. % of a copolymer of an aminoalkyl (meth)acrylate and an alkyl (meth)acrylate. This hydrophilic adhesive mass is excellent in adhesiveness, and especially when combined with a pharmacologically active ingredient, is suitable for use in providing hydrophilic plasters.

Hydrophilic adhesive masses

An anti-inflammatory analgesic plaster carries thereon a base which comprises piroxicam and a polyoxyethylene nonionic surfactant having 5-15 moles of added ethylene oxide.

Anti-inflammatory analgesic plaster

Antiphlogistic-analgesic plaster comprising triacetin and piroxicam

An antiinflammatory and analgesic gel preparation comprising diclofenac or its salts, an ester of dibasic acid, a lower alcohol, and a nonionic polymer or a mixture of nonionic polymers selected from the group consisting of (a) 1.5-4% by weight of hydroxypropyl cellulose having a molecular weight of 500,000 or greater, (b) 2-4% by weight of hydroxyethyl cellulose having a molecular weight of 1,250,000 or greater, and (c) 1.5-4% by weight of a mixture of hydroxypropyl cellulose having a molecular weight of 500,000 or greater and hydroxyethyl cellulose having a molecular weight of 1,250,000 or greater, and having a viscosity of 5,000-35,000 cps and an yield value of 5 dyn/cm.sup.2 or greater. The gel preparation is excellent in the percutaneous absorption of diclofenac or its salts and provides good properties upon use and superior medical effects of diclofenac or its salts.

Antiinflammatory and analgesic gel preparation

Antiinflammatory gel preparation

A diclofenac sodium plaster has a backing material and a paste spread on the backing material. The paste is composed of diclofenac sodium, a penetration enhancer composed of 1-menthol and propylene glycol, and a hydrophilic base composed principally of a water-soluble polymer.

Diclofenac sodium plaster

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Narashino, Japan

Yasuo Ikeda