Nikken Chemicals Co., Ltd.

Institute of Organic Synthesis Academy of Sciences Latvian Ssr.

Yasuo Hoshide

Kenichi Suzuki

Tatsuo Tomioka

Yoichi Inoue

Yoshio Hashimoto

Toshio Matsumoto

Toshio Nakamura

Yohji Yoshida

Hirosi Ogawa

Hirosuke Niwa

1,4-Dihydropyridine compound having the general formula: ##STR1## wherein R and R' are independently a methyl, ethyl, or propyl group. This compound has a remarkable liver protective action and a low toxicity.

1,4-Dihydropyridine compound

5-Fluorouracil derivative having the formula ##STR1## wherein R represents hydrogen atom or 2-tetrahydrofuryl group is produced by reacting more than equi-mole of 2,3-dihydrofuran with 5-fluorouracil in a polar aprotic solvent with a catalytically effective amount of a catalyst selected from the group consisting of metal halides, non-metal halides, tertiary amine salt of inorganic acids and organic acids in neutral or basic condition at 50.degree. to 150.degree. C under pressure.

Process for producing 5-fluorouracil derivative with a calcium chloride

A process for producing a desacetoxy cephalosporanic acid represented by formula (III), ##SPC1## wherein R.sub.1 is acyl, and R.sub.2 is alkyl, aryl or arylalkyl, which comprises: heating a penicillin sulfoxide of the formula (I), ##SPC2## wherein R.sub.1 and R.sub.2 are the same as hereinbefore defined at 50.degree. to 160.degree.C in an inert organic solvent in the presence of a sulfonate represented by formula (II), ##EQU1## wherein A is R.sub.5 --N--R.sub.6, R.sub.5 --N--O--R.sub.6, S--R.sub.6, R.sub.5 --S.fwdarw.O, and R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are lower alkyl, phenyl, benzyl or phenethyl, R.sub.7 is 1-12C alkyl, phenyl, 1-12C alkyl-substituted-phenyl, naphthyl, 1-12C alkyl-substituted naphthyl, halogen-substituted phenyl and wherein when A is R.sub.5 --N--R.sub.6 or R.sub.5 --N--O--R.sub.6, R.sub.3, R.sub.4 and R.sub.5 may form a heterocyclic ring together with the nitrogen atom, and when A is S--R.sub.6, R.sub.3 and R.sub.4 may form a heterocyclic 4-5C polymethylene ring or R.sub.6 and R.sub.7 may bond to form a polymethylene link.

Process for producing desacetoxy cephalosporanic acid compound

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Tokyo, Japan

Yasuo Hoshide