Nippon Chemiphar Co., Ltd.

Kyowa Hakko Kogyo Co., Ltd.

Fuji Chemical Industry Co., Ltd.

Idemitsu Kosan Company, Limited

Rikagaku Kenkyusho

Kyowa Hakko Kogyo Kabushiki Kaisha

Toyotomi Co., Ltd.

Yasuo Fujimoto

Shigeru Yamabe

Keizo Tatsukawa

Toru Yamanaka

Yoshio Suzuki

Yoshihiro Tanaka

Kiyosato Nyu

Shoji Ryu

Nobuhiro Nakamizo

Hiroshi Nakajima

Terumi Tamada

Katsumi Sakai

Masayuki Nagumo

Yoshitaka Inamoto

Kiichi Nagai

Yukio Onogawa

Kuniichiro Ohno

Shigehito Araki

Masashi Yoshida

Koichi Nagaoka

Michio Sugimoto

Masayuki Teranishi

Kosaku Honna

Yasuo Homma

Konomu Kurisaki

Hirozo Sugahara

Kinichi Nakano

Chikahiro Urakawa

Kiyoshi Watanabe

Koh Kusama

Akira Miike

Hiroshi Katagihara

Yasuo Kishi

Tatsuo Nomura

Katsuhiro Ishimi

Yoichi Koiwa

Shinsuke Koshimoto

Shohei Kobayashi

Toru Doiuchi

Tatsuya Tsuru

Fumitada Yamamoto

Yoshiyuki Ichinohe

Syoji Ryu

A hair tonic containing an extract of a plant of the family Julianiaceae such as Juliania adstringens, Amphipterygium adstringens or Orthopterygium huancuy as an active ingredient. The bark of the plant is used as it is or in pulverized or ground form and extracted by using a solvent which does the human body no harm. The extract is so added to the hair tonic that its content on dry basis becomes 2.5.about.25% (w/w) to the whole quantity of the hair tonic.

Hair tonic

A plant disease preventing agent which comprises as an effective ingredient at least one compound represented by the following formula (I) and a carrier: ##STR1## wherein R is selected from group consisting of 4-hydroxy-3-oxopent-1Z-enyl, 4 hydroxy-3-oxopent-1E-enyl, 3,4-dihydroxypent-1E-enyl and 1,4-dihydroxy-3-oxopentyl groups. The agent is effective to prevent melanose spot disease of oranges, stem-end rot disease, grey mold of petunia petals and rice blight.

Plant disease preventing agents

Acetic acid derivatives having the formula, ##STR1## wherein X represents an oxygen or two hydrogen atoms, Y represents CH or N, A represents an oxygen or sulfur atom, and R represents hydroxy, amino or a lower alkoxy group having 1 to 5 carbon atoms possess excellent antiinfammatory activities.

Acetic acid derivatives

A compound of the formula (I), ##STR1## wherein R.sub.1 represents a halogen atom, or a hydroxy, nitro, amino, trihalogenomethyl or lower alkoxy group having 1 to 5 carbon atoms, and R.sub.2 represents a hydroxy or amino group is an antiinflammatory agent.

Dibenzothiepin derivatives and a process for producing the same

Acetic acid derivatives having the formula, ##STR1## wherein X represents an oxygen or two hydrogen atoms, Y represents CH or N, A represents an oxygen or sulfur atom, and R represents hydroxy, amino or a lower alkoxy group having 1 to 5 carbon atoms possess excellent antiinflammatory activities.

Acetic acid derivatives of 5,6-dihydrobenzo[b]pyrido[3,2-f]thiepine and

A compound of the formula, ##STR1## wherein R represents a hydroxy or amino group is an antiinflammatory and analgesic agent.

Hypertension in human is treated by orally administering an effective amount of methylreserpate with little or no undesirable side effect such as central nervous system depression. Methylreserpate can be prepared from Reserpine, a Rauwolfia alkaloid.

Method for treating hypertension with methylreserpate

5-Phenethyl oxazolidone compounds having the formula: ##STR1## wherein R represents a hydrogen or halogen atom or a lower alkoxy group have muscular relaxing, analgetic and antiinflammatory activities.

5-Phenethyl-2-oxazolidone derivatives and a process for producing the

9-(.beta.-hydroxyethyl) piperazinyl-carbonyl-2-trifluoromethyl-10, 11-dihydrodibenzo[b,f]thiepin is prepared and disclosed as having antiinflamatory action.

Benzo[b,f]thiepan derivitives

Penicillin and cephalosporin derivatives and non-toxic salts thereof represented by the formula (1), ##STR1## wherein Ar represents a phenyl or heterocyclic group which may be substituted by a halogen atom, or a hydroxy or lower alkoxy group, R represents a hydrogen atom or a hydroxy group, X represents CH or N, ##STR2## 1 and n are integers of 0 or 1 wherein the sum equal to 1 and n is 0 or 1, and m is an integer equal to 1 or 2 are useful antibiotics.

Penicillin derivatives

Propionic acid derivatives having the formula ##STR1## wherein X represents an oxygen or two hydrogen atoms, Y represents CH or N, A represents an oxygen or sulfur atom, and R represents hydroxy, amino, or a lower alkoxy group having 1 to 5 carbon atoms are antiinflammatory agents.

Propionic acid derivatives

Novel benzo [b,f] thiepin derivatives possessing strong anti-flammatory action and presenting few adverse reactions, of the formula (I) ##STR1## wherein R represents a fluorine atom, or a trifluoromethyl or 1-5C lower alkoxy group, and R.sub.3 and R.sub.4 each represent a 1-4C lower alkyl group or R.sub.3 and R.sub.4 together with the adjacent nitrogen atom to which they are attached form a heterocyclic group. Pharmaceutical compositions comprising an anti-inflammatory effective amount of the compound according to formula (I) in the presence of an inert carrier.

Benzo[b,f]thiepin derivatives and process for producing the same

Dihydrodibenzo[b,f]thiepin compounds of formula (I) and process for making them. These compounds have antiinflammatory action. ##STR1## wherein R represents a hydrogen, fluorine atom, a trifluoromethyl, 1-5C lower alkoxy, hydroxy, hydroxyethoxy, aminoethoxy group or the group of the formula --OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OH, Y represents a hydroxy group or the group of the formula ##STR2## (R.sub.3 and R.sub.4 represent a 1-4C lower alkyl group or R.sub.3 and R.sub.4 may jointly form a heterocyclic group together with an adjacent nitrogen atom.

Benzo[b,f]thiepin derivatives

.alpha.-Cyanoamine compounds represented by the following formula or an acid addition salt thereof ##STR1## WHEREIN R.sub.1 is a halogen atom or lower alkoxy group, R.sub.2 and R.sub.3 are a hydrogen atom or lower alkoxy group, R.sub.4 is a hydrogen atom or lower alkyl group, R.sub. 5 is a hydrogen atom, --COOR.sub.6 (R.sub.6 is lower alkyl group), ##STR2## (R.sub.7 is lower alkoxy group, m is a numeral 0-3), --R.sub.8 --COOR.sub.9 (R.sub.8 is lower alkylene group, R.sub.9 is lower alkyl group), ##STR3## (R.sub.10 and R.sub.11 are a hydrogen atom or lower alkyl group, or R.sub.10 and R.sub.11 jointly form alkylene group), or ##STR4## (R.sub.1 to R.sub.4 are the same as defined above) and n is a numeral 2 or 3; but it is excluded when R.sub.5 is hydrogen atom or --COOR.sub.6 (R.sub.6 is the same as defined above) and n is a numeral 2, which are produced by reacting aromatic carbonyl compounds with piperazine or homopiperazine compounds in the presence of hydrogen cyanide or salts thereof, or which are alternatively produced by reaction N-(.alpha.-cyanobenzyl)-piperazines of N-(.alpha.-cyanobenzyl)homopiperazines or acid addition salts thereof with halogenated compounds.

.alpha.-Cyanoamine compounds and a process for producing the same

5-Benzyl-2-oxazolidone derivatives of the formula: ##STR1## wherein R.sub.1 represents a hydrogen, halogen, lower alkyl, trihalogenomethyl, phenyl, benzyl, hydroxy, lower alkoxy, phenoxy, benzyloxy, acyloxy, allyloxy, alkylcarbonyl, arylcarbonyl or alkylenedioxy group, and R.sub.2 represents a hydrogen atom, a lower alkyl, lower alkylcarbonyl, lower-dialkylamino-lower-alkyl, aryl, aralkyl or arylcarbonyl group.

5-Benzyl-2-oxazolidone derivatives and a process for producing the same

Growing community of inventors

Tokyo, Japan

Yasuo Fujimoto