Mie University

Yasuo Chinzei

Yuki Orito

Haruhiko Isawa

Akihiro Morita

Masao Yuda

The present invention provides Ti-4 protein, which is a protein obtained from salivary gland of, and the present invention provides Ti-4 gene encoding the protein. As the Ti-4 protein exhibits inhibitory activity on platelet aggregation, a medicine comprising the Ti-4 protein as an active ingredient will serve as a platelet aggregation inhibitor possibly effective for prevention and treatment of myocardial infarction, pulmonary infarction and cerebral infarction. Moreover, the Ti-4 protein will also serve as a highly prospective lead compound in the development of novel platelet aggregation inhibitors.

Ti-4 protein derived from Triatoma infestans exhibiting activity to inhibit platelet aggregation

The present invention provides Ti-3 protein, which is a protein obtained from salivary gland of, and the present invention provides Ti-3 gene encoding the protein. As the Ti-3 protein exhibits inhibitory activity on platelet aggregation, a medicine comprising the Ti-3 protein as an active ingredient will serve as a platelet aggregation inhibitor possibly effective for prevention and treatment of myocardial infarction, pulmonary infarction and cerebral infarction. Moreover, the Ti-3 protein will also serve as a highly prospective lead compound in the development of novel platelet aggregation inhibitors.

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Tsu, Japan

Yasuo Chinzei