Kyoto University

Nitto Pharmaceutical Industries, Ltd.

Noster Inc.

Yasunori Yonejima

Jun Ogawa

Shigenobu Kishino

Teruo Kawada

Tsuyoshi Goto

Nobuyuki Takahashi

Sakayu Shimizu

Keiko Hisa

Yoshie Uchibori

Si-Bum Park

Hidekazu Kim

Tatsuya Sugawara

Takashi Hirata

The present invention provides production of hydroxylated fatty acid by a hydration reaction using a novel enzyme derived fromand using fatty acid as a substrate, and further, a production method of oxo fatty acid by an enzyme reaction or chemical oxidation reaction using the hydroxylated fatty acid as a substrate. In addition, a valuable novel rare fatty acid obtained by such production method is also provided.

Method for producing rare fatty acid using novel enzyme, and novel rare fatty acid

The present invention provides a production method of oxo fatty acid, as well as rare fatty acids such as conjugated fatty acid, hydroxylated fatty acid, partially saturated fatty acid and the like, which uses 4 kinds of enzymes (fatty acid-hydratase, hydroxylated fatty acid-dehydrogenase, oxo fatty acid-isomerase, oxo fatty acid-enone reductase) derived fromincluding lactic acid bacteria and the like. Furthermore, the present invention also provides a more efficient production method of oxo fatty acid and the like, which partly uses a chemical oxidation reaction in combination.

Method for producing oxo fatty acid and rare fatty acid

The invention provides a metabolism improving agent containing a rare fatty acid such as hydroxylated fatty acid, oxo fatty acid and the like, and further, food, pharmaceutical product and the like containing the metabolism improving agent.

Metabolism-improving agent comprising rare fatty acid

The present invention provides a metabolism improving agent containing a rare fatty acid such as hydroxylated fatty acid, oxo fatty acid and the like, and further, food, pharmaceutical product and the like containing the metabolism improving agent.

The present invention provides athat improves hyperuricemia, fatty liver and a lifestyle-related disease, and a composition containing the

Lactic acid bacterium and composition including said lactic acid bacterium

The invention provides a HYA derivative having superior physiological functions intrinsic to HYA and permitting easy ingestion and easy handling, and use thereof. In particular, the invention relates to an alkyl ester of 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof, or ester of 10-hydroxy-cis-12-octadecenoic acid with dihydric alkanol or an optical isomer thereof, and a composition (edible fat or oil, food, medicament, cosmetic etc.) containing same.

10-hydroxy-cis-12-octadecenoic acid alkyl ester and use thereof

The invention provides a HYA derivative having superior physiological functions intrinsic to HYA and permitting easy ingestion and easy handling, and use thereof. In particular, the invention relates to a triglyceride in which at least one fatty acid forming an ester bond with a hydroxy group of glycerol is 10-hydroxy-cis-12-octadecenoic acid, or an optical isomer thereof, and a composition (edible fat or oil, food, medicament, cosmetic etc.) containing same.

Triglyceride and use thereof

The present invention provides a metabolism improving agent comprising an oxo fatty acid having 18 carbon atoms and a carbonyl group at the 10- or 12-position, and/or a hydroxy fatty acid having 18 carbon atoms and a hydroxyl group at the 10- and/or 12-position(s), and use of the metabolism improving agent as a food, a pharmaceutical product and the like.

The present invention provides an intestinal tract-protecting agent, an agent for the prophylaxis or improvement of a disease caused by damage in intestinal tract barrier function, which contains hydroxylated fatty acid, particularly hydroxylated unsaturated fatty acid, having a hydroxyl group at the 10-position and/or the 12-position, which is an intermediate of the metabolism of unsaturated fatty acid by

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Muko, Japan

Yasunori Yonejima