Ajinomoto Co., Ltd.

Other

Yasunori Yokogawa

Hiroshiro Shibai

Koichi Ishii

Yuzuru Eto

Satoshi Takano

Masahiko Okunishi

Tomoko Tsuji

Ryosaku Noumi

Misako Takezawa

Chuji Hirata

Tsutomu Tabira

Yasuo Komoda

A physiologically active polypeptide, BUF-3, having the ability to differentiate and maturate human leukemia cells into normal cells and of accelerating the formation of erythroblasts is disclosed. The polypeptide has a molecular weight of 16.+-.1 Kd as determined by SDS-electrophoresis in the presence of 1% mercaptoethanol, or 25.+-.1 Kd, as determined by SDS-electrophoresis in the absence of mercaptoethanol.

Polypeptide capable of differentiating and maturing malignant cells into

An antimycotic agent having a high degree of antimicrobial activity towards Eumycetes and with a level of toxicity lower than that of heptaene antibiotic V-28-3 is disclosed. This compound is a methyl ester derivative of heptaene antibiotic V-28-3.

Heptaene V-28-3 antibiotic derivative

NaOH.3.5 H.sub.2 O crystals are prepared by cooling a slurry of 32 to 34% aqueous NaOH solution containing NaOH.3.5 H.sub.2 O seed crystals to below the temperature for saturating the aqueous NaOH solution with respect to NaOH.3.5 H.sub.2 O and separating the precipitated crystals.

Process for preparing NaOH.3.5 H.sub.2 O crystals

Growing community of inventors

Kanagawa, Japan

Yasunori Yokogawa