Nippon Shokubai Co., Ltd.

Japan Science and Technology Agency

Wako Pure Chemical Industries, Inc.

Yasunori Yamamoto

Norio Miyaura

Tetsuya Yamamoto

Yasutaka Nakatani

[Problem] To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. [Means for Solving Problems] The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein Rrepresents alkyl, alkenyl, etc.; Rrepresents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; mrepresents an alkaline metal ion, phosphonium ion, or given ammonium ion; Mrepresents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).

Reagent for organic synthesis reaction containing organic triol borate salt

Compounds represented by the following general formula (1a) or (1b). A complex comprising a center metal of rhodium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for optically active beta-substituted carbonyl compound synthesis and catalyst for asymmetric 1, 2 addition reaction being composed of the complex. A method of production of an optically active beta-aryl compound from an alpha, beta-unsaturated compound and an aryl-boronic acid derivative and method of production of an optically active aryl alcohol compound from an aldehyde compound and aryl boronic acid derivatives using the catalyst. A complex comprising a center metal of palladium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for asymmetric allylic substitution reaction being composed of the complex. A method of production of an optically active dialkyl (1,3-disubstituted propeny)malonate compound from a 1,3-disubstituted ally acetate compound and a dialkyl malonate and method of production of an optically active allylamine compound from a 1,3-disubstituted ally acetate compound and an amine compound. The compounds have not only the versatility of being usable in the synthesis of wide-ranging optically active aryl compounds but also the selectivity and reactivity permitting synthesis with high yield within a short period of time under industrially advantageous mild conditions.

Catalyst for asymmetric synthesis, ligand for use therein, and process for producing optically active compound through asymmetric synthesis reaction using them

In synthesis of hexaalkylborazine represented by the chemical formula 2 from a borazine compound represented by the chemical formula 1, a borazine compound represented by the chemical formula 1 is reacted with an alkene compound, in the presence of a catalyst. Wherein Rs may be the same or different and each Rrepresents an alkyl group; and each Rrepresents a hydrogen atom or an alkyl group, and at least one of Rs represents a hydrogen atom; and Rs may be the same or different and each Rrepresents an alkyl group. 

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Sapporo, Japan

Yasunori Yamamoto