Hisamitsu Pharmaceutical Company, Inc.

Toppan Printing Co., Ltd.

Maruto Sangyo Co., Ltd.

Yasunori Takada

Takashi Yasukochi

Koji Tanaka

Yasuhiro Ikeura

Hiroaki Okutsu

Masayuki Suzuki

Atsushi Sonobe

Kiyomi Tsuruda

Tsuguki Nishihara

Atsushi Matsushima

Chiaki Yoshida

Tsuyoshi Takamiya

Naruhito Higo

Kanji Noda

Akira Nakagawa

Shigeo Suzuki

Munehiko Hirano

Takaaki Terahara

Yasuhisa Kose

Yuka Takagi

Masaru Saita

Naoyuki Uchida

Takito Shima

Yasuaki Taniguchi

Tomohiro Shinoda

Miyuki Shinmura

Tetsurou Tateishi

Eisuke Hatanaka

Akio Takeuchi

Terushi Hashiguchi

Motohiro Suzuki

Eiji Kyoya

Hisaaki Isaji

Yoshiaki Hashimoto

Kenji Atarashi

Koichi Ikesue

Shinichi Yokota

Tomonori Kurita

In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.

Patch

A method for producing a patch including a support layer, and an adhesive agent layer formed on the support layer and including sodium diacetate, a pressure-sensitive adhesive base agent, and asenapine and/or a pharmaceutically acceptable salt thereof. The sodium diacetate is generated from sodium acetate in the presence of the asenapine and/or salt thereof, a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is in range of 3.0 to 20 mg, and when a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is 6.4 mg and the patch is in contact with skin for 24 hours, Cof free asenapine is in range of 0.5 to 6.0 ng/mL and tof free asenapine is in range of 8 to 28 hr.

Patch and method for producing the same

A patch for administering asenapine includes a support layer, and an adhesive agent layer formed on the support layer and including an adhesive base agent and asenapine and/or a pharmaceutically acceptable salt thereof. The adhesive base agent has a content in a range of 10 to 90% by mass in the adhesive agent layer and includes a natural rubber, polyisobutylene, an alkyl vinyl ether(co)polymer, polyisoprene, polybutadiene, a styrene-butadiene copolymer, a styrene-isoprene copolymer, a styrene-isoprene-styrene block copolymer, or a combination thereof. When a content of the asenapine and/or pharmaceutically acceptable salt thereof in terms of free asenapine in the adhesive agent layer is 3.4 mg, an AUCfor a period starting from the time when the patch is brought into contact with a skin for 24 hours is 27,000 pg&#xb7;hr/mL or more, and an AUCof an asenapine metabolite is 20% or less of the AUCof the free asenapine.

A method for producing a patch comprising a support layer and an adhesive agent layer comprises:

A patch comprises a backing and an adhesive layer laminated on at least one surface of the backing, in which the adhesive layer contains at least one selected from the group consisting of fentanyl and salts thereof, and contains an adhesive base material and an antioxidant having a sulfur atom in its molecule.

The present invention provides a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein R is a hydrogen atom, a Calkyl group optionally substituted with one or more hydroxyl groups, a Calkoxy group, or a cyano group.

Roflumilast prodrugs

In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, isopropyl palmitate, and an adhesive base agent.

A support film for tape which is used for a tape, the support film for tape includes: a film-shaped support formed of polyurethane; and a barrier layer which includes a water-soluble polymer compound and montmorillonite and is formed on one surface of the support. The support film for tape has a percentage content of the montmorillonite in the barrier layer is equal to or more than 2 percent by weight and equal to or less than 22 percent by weight.

Support film for tape and tape

A patch comprising a support layer and an adhesive layer, wherein the adhesive layer comprises diclofenac sodium, dimethyl sulfoxide, and citric acid; a mass ratio between the diclofenac sodium and the citric acid (mass of diclofenac sodium:mass of citric acid) is 1:0.15 to 1:0.45; and a mass ratio between the diclofenac sodium and the dimethyl sulfoxide (mass of diclofenac sodium:mass of dimethyl sulfoxide) is 1:0.75 to 1:3.

Adhesive patch comprising diclofenac sodium

The present invention relates to a transdermal preparation having a backing and an adhesive layer laminated on the backing, wherein the adhesive layer contains 4-ethylene-2(3H)-indolone and a physiologically active compound, and wherein the 4-ethylene-2(3H)-indolone is present in an amount from 0.001 to 4 mass % of the total mass of components of the adhesive layer.

Transdermal preparation comprising a ropinirole derivative

A support film for tape which is used for a tape includes a film-shaped support formed of polyurethane, a barrier layer which includes polyvinyl alcohol and a layered inorganic compound and is formed on a surface of the support, and an undercoat layer which is disposed between the support and the barrier layer, and which causes the support and the barrier layer to adhere to each other.

Growing community of inventors

Tsukuba, Japan

Yasunori Takada