Zymogenetics, Inc.

Yasunori Ikeda

Eileen R Mulvihill

Suguru Suzuki

Akira Hashimoto

Shinji Yoshitake

Bjorn A Nexo

Teruaki Yuzuriha

Tissue plasminogen activator analogs containing the growth factor domain of native t-PA, the domain having at least one cysteine residue replaced with another amino acid. The t-PA analogs may further contain a variety of substitutions and/or modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along With a physiologically acceptable carrier or diluent are also disclosed.

Tissue plasminogen activator analogs having modified growth factor

Tissue plasminogen activator analogs exhibiting greater specificity for fibrin than native t-PA are disclosed. The analogs include the K1 domain of native t-PA replaced with another kringle domain mediating the binding of the analog to fibrin. The kringle contains six cysteine residues. The t-PA analogs may further include a variety of substitutions and modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along with a physiologically acceptable carrier or diluent are also disclosed.

Modified t-PA with kringle-/replaced by another kringle

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Ushiku, Japan

Yasunori Ikeda