Taisho Pharmaceutical Co., Ltd.

Toyama Chemical Co., Ltd.

Meiji Seika Pharma Co., Ltd.

Yasunobu Ushiki

Satoshi Yoshida

Fumihito Ushiyama

Yasuhiro Tsutsui

Hiroki Urabe

Tadashi Tanaka

Taro Kiyoto

Toshiya Noguchi

Junichi Ando

Yasuko Kawaguchi

Mai Motono

Hiroshi Ohta

Tsuyoshi Shibata

Toru Yamaguchi

Masato Hayashi

Masato Kashimura

Naoya Ono

Eiki Shitara

Tomohiro Sugimoto

Tomoaki Miura

Keiji Tamura

Haruhisa Ogita

Kenichi Kanemoto

Tetsuya Tanikawa

Shoichi Kuroda

Kou Kumura

Kanako Yamamoto

Fumito Uneuchi

Naoki Sasamoto

Kenichi Kawabe

Jun Kurosaka

Risa Tsuruta

Hideaki Tabuse

Noritomo Fujino

Keiko Yamamoto

Eiji Munetomo

Sumi Chonan

Ayumu Mori

The present invention provides a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof which has an excellent NHE3 inhibitory effect:A-Y&#x2003;&#x2003;[1]wherein  

Phenyl tetrahydroisoquinoline compound substituted with heteroaryl

A macrolide compound represented by the formula (I) effective against erythromycin resistant bacteria (for example, resistant pneumococci, streptococci and mycoplasmas). 

C-4&#x2033; position substituted macrolide derivative

An amidine compound represented by formula (I) (wherein Arepresents a nitrogen atom or a group represented by formula CR; Aand Aare the same as or different from each other and independently represent a nitrogen atom or a group represented by formula CH; Rrepresents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; Rand Rare the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a Calkyl group, a Chaloalkyl group or a Calkoxy group; and Rand Rare the same as or different from each other and independently represent a hydrogen atom, a Chaloalkyl group, a Calkyl group or the like) or a salt thereof. The compound is useful as an anti-fungal agent.

Amidine compound or salt thereof

A nitrogen-containing heterocyclic compound or pharmaceutically acceptable salt thereof represented by the general formula: which have a potent antibacterial activity and a high safety. Thus, the compounds are useful as antibacterial agents against gram-positive bacteria, gram-negative bacteria and drug resistant bacteria.

Quinolinones and quinoxalinones as antibacterial composition

Quinoxalinones as antibacterial composition

Growing community of inventors

Tokyo, Japan

Yasunobu Ushiki