Shionogi Company Limited

Yasunobu Ishihara

Nobuhiro Haga

Susumu Kamata

Sanji Hagishita

Shigeru Matsutani

Kaoru Seno

Toshiro Konoike

Masami Doteuchi

Yukio Mizushima

Yasushi Murakami

Benzodiazepine derivative

Carbamoylmethylurea derivatives

9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives of the formula: ##STR1## wherein n is 0 or 1, R is --COR.sup.1, --CONR.sup.4 R.sup.5 or --CH.sub.2 R.sup.6, R.sup.1 is C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.7 cycloalkyl, allythio, styryl, phenoxymethyl, thienylmethyl, C.sub.6 -C.sub.10 aryl optionally substituted, benzyl optionally substituted or 5- or 6-membered heterocyclic group optionally substituted, R.sup.2 and R.sup.3 each is hydrogen, C.sub.1 -C.sub.5 alkyl, carboxy, C.sub.2 -C.sub.5 alkoxycarbonyl or benzyloxycarbonyl optionally substituted, R.sup.4 and R.sup.5 each is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.7 cycloalkyl or phenyl optionally substituted, and R.sup.8 is pyridyl or phenyl optionally substituted) being useful as antiulcer agents are provided through several routes.

9-(Substituted thio)-4H-pyrido[1,2,-A]pyrimidin-4-one derivatives

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Kyoto, Japan

Yasunobu Ishihara