Olympus Corporation

Evident Corporation

Yasunobu Iga

Shinichi Takimoto

Shinichi Mihara

Koji Matsumoto

Keisuke Ichikawa

Keigo Matsuo

Kanato Adachi

Kazuaki Murayama

Hideki Nagata

Takashi Miyoshi

Shintaro Takahashi

Yohei Tanikawa

Yoshinobu Akahori

Taiji Mine

Tadashi Hirata

Takeshi Suga

Koji Sakai

Tomoki Funakubo

Mitsuru Namiki

Atsuyoshi Shimamoto

Kazunari Tokuda

Masahiro Yoshino

Masaru Mizunaka

Chikashi Ota

An endoscope system according to the present invention includes: an illumination light source that emits illumination light for illuminating an object; a therapeutic light source that emits therapeutic light for causing a photoreactive reagent accumulated in a treatment target site to react; a guide light source that emits guide light having a wavelength shorter than a wavelength band of the therapeutic light source; an imager that captures an optical image, the imager including an optical filter that cuts light in the wavelength band of the therapeutic light and transmits a part of white light, the guide light, and fluorescence emitted by the reagent; a controller that controls emission timings of the illumination light source, the therapeutic light source, and the guide light source; and an image processor that generates an image on the basis of an optical image obtained by light emitted from the illumination light source, the therapeutic light source, and the guide light source, in which the controller causes the image processor to generate an illumination light image based on an optical image acquired during a period in which the illumination light source and the guide light source are ON and to generate a fluorescence image based on a fluorescence image acquired during a period in which the therapeutic light source is ON and the illumination light source and the guide light source are OFF.

Endoscope system

A cell analyzing device includes a control circuit. The control circuit acquires data of an observation image. The control circuit specifies a colony of a cultured cell in the observation image. The control circuit calculates a ratio at which the cultured cell occupies a predetermined range included in the observation image as an occupancy rate. The control circuit calculates a size of the colony. The control circuit determines a state of the cultured cell based on the occupancy rate and the size of the colony.

Cell analyzing device and cell analyzing system

A cell observation system according to the present invention includes: a first image-acquisition device disposed in an incubator and acquires a first image of cells in a culturing vessel; a second image-acquisition device disposed outside the incubator; a processing device connected to the first image-acquisition device and the second image-acquisition device; and a display displays at least a region of the first image, as well as the second image. The second image-acquisition device includes a second image-acquisition unit that acquires a second image of the interior of the culturing vessel, that removed from the incubator. The processing device extracts target cells in the first image, calculates positions at which the extracted target cells are present and stores the positions in the memory, and causes the display to display the positions at which the target cells are present in a superimposed manner on an indication indicating the culturing vessel.

Cell observation system

A cell observation system according to the present invention includes: a first image-acquisition device disposed in an incubator and acquires a first image of cells in a culturing vessel; a second image-acquisition device disposed outside the incubator; a processing device connected to the first and second image-acquisition devices; and a display. The second image-acquisition device includes a second image-acquisition unit that acquires a second image of the interior of the culturing vessel that removed from the incubator, a support that supports the second image-acquisition unit and the culturing vessel, and a position measuring unit that measures a position between the culturing vessel and the second image-acquisition unit at the time of acquiring the second image. The processing device extracts target cells in the first image, calculates positions of the target cells, and displays the relationship between the positions of the target cells and the second image.

A culture information processing device includes: a feature value computing unit that computes growth feature values indicating features of growth characteristics of cells from data acquired in a particular first subculturing process selected from among a plurality of subculturing processes included in a culture period of the cells; a condition setting unit that sets culturing conditions of a second subculturing process one process after the first subculturing process; and an information computing unit that computes, on the basis of the growth feature values computed by the feature value computing unit and the culturing conditions set by the condition setting unit, characteristics-related information related to growth characteristics in the second subculturing process.

Culture information processing device

For the purpose of counting the number of cells within a culture container readily and accurately, a cell analysis device includes a cell-image acquiring unit that acquires an image of cells within a culture container in which the cells are cultured, a usability determining unit that determines whether or not the image acquired by the cell-image acquiring unit is usable, a number-of-cells counting unit that counts the number of cells within the image determined as being usable by the usability determining unit, and a number-of-cells calculating unit that calculates the number of cells within the culture container based on the number of cells counted by the number-of-cells counting unit.

Cell analysis device and cell analysis method

A cell analysis apparatus including: a cell image acquisition unit that acquires an image of cells in a culture vessel in which cells are cultured; a smoothing processing unit that smooths luminance values in the image acquired by the cell image acquisition unit; a minimum-value detecting unit that detects minimum values of the luminance values smoothed by the smoothing processing unit; a smallest-minimum-value extracting unit that extracts smallest minimum values which are the smallest in regions according to the sizes of the cells, from the minimum values detected by the minimum-value detecting unit; a counting unit that counts the number of smallest minimum values extracted by the smallest-minimum-value extracting unit; and a cell-count calculating unit that calculates the number of cells in the culture vessel on the basis of the number of smallest minimum values counted by the counting unit.

Cell analysis apparatus and method

Provided is an observation apparatus and an observation method with which it is possible to observe imaging subjects, such as cells or the like, without labeling the imaging subjects and without causing an increase in the apparatus size. Provided is an observation apparatus including: a light-source unit that emits illumination light upward from below a sample; and an image-capturing optical system that has an objective lens that collects transmitted light, which is the illumination light emitted from the light-source unit that has passed through the sample by being reflected above the sample and that captures, below the sample, the transmitted light collected by the objective lens.

Observation apparatus and observation method to observe a sample with reflected light transmitted through the sample

A device for sustained release of optical clearing agent includes a stick-shaped component having at least two supplying passages for supplying gas or liquid formed on the inside with apertures of the supplying passages being formed at positions along the circumference of the lateral surface in the vicinity of the top end of the stick-shaped component respectively, at least two pouch-shaped elastic components placed at positions along the circumference of the lateral surface in the vicinity of the top end of the stick-shaped component respectively to cover the apertures of the supplying passages respectively, an optical clearing agent holding component fixed on the surface of one of the pouch-shaped elastic components and holding optical clearing agent, and a body-fluid absorbing component fixed on the surface of another one of the pouch-shaped elastic components and absorbing body fluid flowing from a target object or dehydrating the target object by osmotic pressure.

Device for sustained release of optical clearing agent, endoscope having the same, and instrument for endoscopic surgery having the same

An endoscope has an insertion portion inserted through a living body, an illumination fiber arranged at a distal end of the insertion portion and irradiates the living body with illumination light, a detection fiber which detects return light from the living body, an actuator which swings a free end of the illumination fiber, and a ferrule which has a through-hole based on a diameter of the illumination fiber and is arranged between the illumination fiber and the actuator. The actuator has an actuator arranged at a first side face of the ferrule and an actuator arranged at a second side face of the ferrule that is different from a face point-symmetric to the first side face with respect to an axial direction of the illumination fiber.

Endoscope and endoscope apparatus having piezoelectric element which swings a free end of an optical element through a joining member

An image forming optical system according to the present invention is characterized in that, in an image forming optical system having a positive lens group, a negative lens group, and an aperture stop, the positive lens group is disposed at an object side of the aperture stop, Here, Nd denotes a refractive index, and &#x3bd;d denotes an Abbe's number.

Image forming optical system and electronic image pickup apparatus using image forming optical system

In an image forming optical system having a positive lens group, a negative lens group, and an aperture stop, the positive lens group being disposed at an image-plane side of the aperture stop and having a cemented lens, and when a straight line indicated by Nd=&#x3b1;&#xd7;&#x3bd;d+&#x3b2; (where, &#x3b1;=&#x2212;0.017) is set, Nd and &#x3bd;d of at least one lens forming the cemented lens are included in both an area which is determined by a line when a lower limit value is in a range of a following conditional expression (1), and a line when an upper limit value is in a range of the following conditional expression (1), and in an area determined by following conditional expressions (2) and (3)1.45&#x3c;&#x3b2;&#x3c;2.15&#x2003;&#x2003;(1)1.30&#x3c;Nd&#x3c;2.20&#x2003;&#x2003;(2)3&#x3c;&#x3bd;d&#x3c;25&#x2003;&#x2003;(3) Here, Nd denotes a refractive index, and &#x3bd;d denotes an Abbe's number.

An optical system has a positive lens group, a negative lens group, and an aperture stop. The negative lens group is disposed at an object side of the aperture stop and has a cemented lens, and in a rectangular coordinate system in which a horizontal axis is Nd and a vertical axis is &#x3bd;d, when a straight line indicated by Nd=&#x3b1;&#xd7;&#x3bd;d+&#x3b2; where &#x3b1;=&#x2212;0.017 is set, Nd and &#x3bd;d of at least one lens forming the cemented lens are included in both an area determined by a line when a lower limit value is in a range of expression (1) and a line when an upper limit value is in a range of the expression (1), and an area determined by expressions (2) and (3): 1.45&#x3c;&#x3b2;&#x3c;2.15 (1); 1.30&#x3c;Nd&#x3c;2.20 (2); and 3&#x3c;&#x3bd;d&#x3c;12 (3); where Nd denotes a refractive index, and &#x3bd;d denotes an Abbe's number.

In an image forming optical system having a positive lens group, a negative lens group, and an aperture stop, the negative lens group is disposed at an image side of the of the aperture stop, Here, Nd denotes a refractive index, and &#x3bd;d denotes an Abbe's number.

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Tokyo, Japan

Yasunobu Iga