Meiji Seika Kaisha, Ltd.

Yasumitsu Kondo

Takashi Shomura

Taro Niida

Hiroshi Watanabe

Shigeharu Inouye

Yasuaki Ogawa

Michio Kojima

Yujiro Yamada

Kazuo Saito, Deceased

Takashi Tsuruoka

Masaji Sezaki

Tetsuro Watanabe

Kazunori Ohba

Junko Yoshida

Tatsuo Itoh

Shigeharu Inoje

Kazuo Okano

Novel antibiotic SF-2288 is produced by fermentation of an actinomycete belonging to the genus Actinomadura in nutrient medium. Based on its physico-chemical and biological properties, antibiotic SF-2288 possesses an excellent antimicrobial activity against Gram-positive and Gram-negative microorganisms and antiviral activity.

Antibiotic SF-2288 and its preparation method

A novel antibiotic substance SF-1540 and a process for preparing the same which comprises culturing a substance SF-1540-producing microorganism belonging to the genus Streptomyces in a medium and isolating and recovering the substance SF-1540 from a cultured broth; a novel derivative of the substance SF-1540 and a process for preparing the same which comprises treating said antibiotic substance SF-1540 with methanol to form the corresponding antibiotic substance SF-1540 derivative.

Novel antibiotic substance SF-1540 and its derivative, and process for

Novel antibiotics derivatives 7-(5-acylamido-5-carboxyvaleramido)-3-(.alpha.-methoxy-p-acyloxycinnamoylo xymethyl)-7-methoxy-3-cephem-4-carboxylic acids and the salts thereof which are useful as antibiotics and intermediates for the preparation of cephamycin derivatives, a process for preparing the same, and a process for recovering the cephamycin derivatives effectively and stably from the fermentation broth in the form of an N-acyl derivative.

Novel antibiotics derivatives and process for preparing the same

A new antibiotic designated as SF-1623 substance exhibiting a useful antibacterial activity against gram-negative bacteria is now produced by cultivating a new strain ATCC 21999 of the known species Streptomyces chartreusis. The SF-1623 substance in the form of its an alkali metal salt may be recovered from the culture when the cultivation is effected under aerobic conditions in the presence of an alkali metal thiosulfate.

Antibiotic SF-1623 substance and the production thereof

Antibiotic SF-1623 substance

This invention relates to a process for preparing a cephamycin type antibiotic substance which comprises cultivating a microorganism belonging to the genus Streptomyces under aerobic conditions and a primary object of this invention is to provide a process for preparing the said product on a simple and industrial scale.

Process for preparing a cephamycin type antibiotic substance

Growing community of inventors

Yokohama, Japan

Yasumitsu Kondo