Kowa Company Limited

Yasumi Uchida

Seiichi Sato

Yoshinori Kyotani

Masami Shiratsuchi

Hiromichi Shigyo

Tomio Ohta

Kiyoshi Kawamura

Noboru Shimizu

Toshihiro Akashi

Hiroshi Ishihama

Masahiko Nagakura

Hisashi Kunieda

Naotoshi Sawada

Takashi Yamaguchi

Kimiyuki Shibuya

Tadaaki Ohgiya

Kazuhiro Onogi

Tsutomu Toma

Yoshio Takahashi

Sohei Tanabe

Toshiaki Oda

Hiroyuki Ishiwata

Takahiro Kitamura

Katsumi Kawamine

Yukihiro Okuno

Yuji Kurihara

Mitsuo Kawada

Mikio Fujii

Quinoline derivatives or salt thereof and remedy for cardiac diseases

An indole derivative represented by formula (1), ##STR1## wherein A is a group ##STR2## wherein R.sup.10 is hydrogen or lower alkyl, dotted lines may optionally be present, and R.sup.1 -R.sup.9 represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.

Indole derivatives, salts thereof, and congestive heart failure

A propane derivative represented by the following formula ##STR1## wherein R represents a lower alkyl group; one of A and B represents a group of the formula ##STR2## and the other represents a group of the formula ##STR3## in which R.sup.1 and R.sup.2 are identical or different and each represents a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, R.sup.3 represents a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group, and X represents a sulfonyl group or a carbonyl group, and an acid addition salt thereof. The compounds provided by this invention have useful biological activities such as the spasmolytic activity on the vascular smooth muscles and anti-platelet aggregatory activity and are useful as drugs for treating cardiovascular diseases such as angina pectoris, cerebral circulation disorder and thrombosis.

Piperazines and homopiperazines

A sulfonamide compound represented by the following formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are identical or different, and each represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R.sup.4 represents a hydrogen atom, a lower alkyl group, or a substituted or unsubstituted aralykyl group; R.sup.5 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted aralkyl group; R.sup.6 and R.sup.7 are identical or different and each represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; and n is an integer of 1 to 8, and an acid addition salt thereof. The compounds of formula (I) provided by this invention have some useful biological activities such as the spasmolytic activity on the vascular smooth muscles and anti-platelet aggregatory activity and are useful as drugs for treating cardiovascular disorders such as angina pectoris, cerebral circulation disorder and thrombosis.

Sulfonamid compound useful for treating cardiovascular disorders

A substituted anilide derivative of the formula ##STR1## wherein R.sub.1 represents a mononuclear or binuclear heterocyclic group which contains 1 to 3 nitrogen atoms as ring members and may have a substituent.

Substituted anilide compounds which are useful in the treatment of

Anti-arteriosclerotic pyridyl or imidazolyl derivatives of

A novel racemate K-351A composed of an optical isomer (2'S),(3S)K-351 [3,4-dihydro-8-(2'-hydroxy-3'-isopropylamino)propoxy-3-nitroxy-2H-1-benzop yran] and (2'R),(3R)K-351, a novel racemate K-351B composed of an optical isomer (2'R),(3S)K-351 and (2'S),(3R)K351 and an acid addition salt of these two novel racemates; a process for converting the two racemates to each other; and also to a pharmaceutical composition comprising each of the two racemates useful for the treatment of cardiovascular diseases.

Racemates of

An optical isomer selected from the group consisting of (2'R),(3R)-3,4-dihydro-8-(2'-hydroxy-3'-isopropylamino)propoxy-3-nitroxy-2 H-1-benzopyran, (2'S),(3R)-3,4-dihydro-8-(2'-hydroxy-3'-isopropylamino)propoxy-3-nitroxy-2 H-1-benzopyran and acid addition salts of these isomers, process for producing these isomers and a pharmaceutical composition thereof useful for the treatment of cardiovascular diseases.

Optical isomers, processes for production thereof and pharmaceutical

A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --O--CH.sub.2 --,

Aromatic aminoethanol compounds, and utilization thereof as

A compound represented by the following formula ##STR1## wherein R represents a lower alkyl group having 2 to 6 carbon atoms, and n is an integer of from 1 to 5.

N-Nitroxyalkylene benzamide derivatives

A benzopyran compound represented by the following ##STR1## wherein A represents a direct bond or the bond --CH.sub.2 --O--,

Dihydrobenzopyran compounds and pharmaceutical composition comprising

A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --0--CH.sub.2--,

Certain phenyl or pyridyl-propanol-amines containing alkyl-nitrate

Growing community of inventors

Ichikawa, Japan

Yasumi Uchida