Fujisawa Pharmaceutical Company, Ltd.

Yasumasa Tsukitani

Hiroyuki Kikuchi

Masanori Fukushima

Yasuji Yamada

Toshitaka Manda

Osamu Hirai

Iwao Shimizu

Novel clavulone derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 combine together to form a keto group or either one of R.sup.1 and R.sup.2 is hydrogen atom and another one of them is hydroxy or acetoxy group, R.sup.3 and R.sup.4 are the same or different and are each hydrogen atom or acetoxy group, n is 0 or 1, provided that when the C--C bond between 8 and 12 positions is double bond, n is 0, a, b, c, d and e are each an integer of 1 or 2, and the dotted line means that the C--C bond is a single bond or double bond, or a salt thereof, which have excellent anti-inflammatory activity and anti-tumor activity and hence are useful as an anti-inflammatory agent or anti-tumor agent.

Growing community of inventors

Sakuramura, Japan

Yasumasa Tsukitani