Takeda Pharmaceutical Company Limited

Takeda Chemical Industries, Inc.

Yasuko Terao

Takuya Watanabe

Yasushi Shintani

Chieko Kitada

Tetsuya Ohtaki

Shuji Hinuma

Ryo Fujii

Masaki Hosoya

Shoji Fukusumi

Yasushi Masuda

Yoshihiro Takatsu

Kimiko Kanehashi

Kuniko Kikuchi

Syuji Hinuma

The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.

Use of a G protein-coupled receptor and its cognizant ligand in the identification of compounds that affect prolactin secretion

The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.

Screening assay using G-protein coupled receptor protein OT7T175

The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity of the peptide, a compound or its salt obtained by the screening, a drug comprising the compound or its salt, etc. The peptide of the invention and the DNA encoding the same are usable, e.g., for the diagnosis, treatment, prevention, etc. of digestive diseases, etc. Moreover, the peptide of the invention is useful as a reagent for screening a compound or its salt that promotes or inhibits the activity of the protein of the invention.

Isolated physiologically active peptide and use thereof

The present invention relates to a polynucleotide encoding a human brain-derived G protein coupled receptor protein. The human brain-derived G protein coupled receptor protein is useful: (1) for determination of a ligand to the receptor protein, (2) as an agent for the prevention and/or treatment of diseases associated with dysfunction of the receptor protein, (3) as a genetic diagnostic agent, (4) for quantification of a ligand to the receptor protein, (5) for screening of a compound that alters the binding property between the receptor protein and a ligand, (6) as an agent for the prevention and/or treatment of various diseases, comprising a compound that alters the binding property between the receptor protein and a ligand, (7) for quantification of the receptor protein, (8) for neutralization by antibodies to the receptor protein and (9) for preparation of a non-human animal bearing the DNA encoding the receptor protein.

Polynucleotide encoding the hOT7T175 G protein coupled receptor

G protein-coupled receptor protein, its DNA and ligand thereof

Physiologically active peptide and use thereof

G Protein-coupled receptor proteins originating in the vicinity of rat brain stem and human brain or salts thereof, or peptide fragments thereof or amides, esters or salts of the same; ligands thereto; a method/kit for screening compounds capable of altering the binding properties of the ligands to the G protein-coupled receptor proteins; the compounds or salts thereof obtained by the above screening; antibodies against the G protein-coupled receptor proteins, etc.

Peptides that activate the G-protein coupled receptor protein, 0T7T175

Growing community of inventors

Hyogo, Japan

Yasuko Terao