Sogo Pharmaceutical Co., Ltd.

Mitsubishi Jukogyo Kabushiki Kaisha

Yasuko Osawa

Saburo Uchikuga

Tomoyasu Tashiro

Manabu Katsumata

Kiichiro Ogawa

Yuji Narutomi

Junsuke Miyake

The present invention has been realized in order to treat noxious and combustible gases, which are exhausted during the start-up operation of a composite coal gasification-power plant and/or released from various safety valves arranged in such power plant and which have hitherto been discharged without treatment into the atmosphere, to make it innoxious and to attain an efficient energy utilization and concerns an improvement of such a composite coal gasification-power plant, which is characterized either in that an additional combustion unit is disposed parallel to the burner of the gas-turbine electric power generating unit and is arranged so as to supply the combustion exhaust gas of this additional combustion unit to as to supply the combustion exhaust gas of this additional combustion unit to the waste heat boiler, or in that an additional combustion unit, operative to effect to burn the noxious and combustible gases exhausted from the burner during start-up and/or those released from safety valves arranged in the power plant and to supply the combustion exhaust gas to said waste heat boiler, is arranged.

Combined power generating plant

The present invention concerns an enzyme inhibitor containing the compound represented by the following formula (I) as an effective ingredient: ##STR1## where R represents hydrogen or substituted or not substituted alkyl group, alkenyl group, aryl group or aralkyl group, X represents OR' or NR'R'', in which R', R' and R'' represent respectively hydrogen or substituted or not substituted alkyl group, alkenyl group, aryl group or aralkyl group. The enzyme inhibitor according to the present invention can effectively inhibit aldose reductase, glyoxalase I and reverse transcriptase.

Pyrroloquinoline quinone compounds useful as an enzyme inhibitor

Cimetidine, namely N-cyano-N'-methyl-N'-[2-((4-methyl-5-imidazolyl) methylthio) ethyl] guanidine which is useful as an antagonist of H.sub.2 -receptor is prepared by reacting 4-methyl-5-[(2-aminoethyl) thiomethyl] imidazole, which is obtained by the reaction of 4-methyl-5-hydroxymethylimidazole on 2-aminoethanethiolsulfuric acid, with O-alkyl-S-alkyl-cyanothioimidocarbonate to give N-cyano-N'-[2-((4-methyl-5-imidazolyl) methylthio) ethyl]-O-alkylisourea, which is reacted with monomethylamine. According to the present process, cimetidine can be prepared in good yield and desired purity with very reduced amount of methyl mercaptan released from the reaction.

Process for preparing the H.sub.2 -receptor antagonist cimetidine

A method for preparing 2,2-disubstituted thiazolidine involves reacting aminoalkyl hydrogen-sulfate with a compound having hydrosulfide ion in the presence of ketone. According to the present method, such thiazolidine can be prepared in good yield and desired purity without using harmful ethylenimine as a starting material.

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Tokyo, Japan

Yasuko Osawa