Taisho Pharmaceutical Co., Ltd.

Toyama Chemical Co., Ltd.

Fujifilm Toyama Chemical Co., Ltd.

Yasuko Kawaguchi

Hiroki Urabe

Masato Takahashi

Tadashi Tanaka

Taro Kiyoto

Tetsuya Yabuuchi

Hajime Takashima

Fumihito Ushiyama

Yusuke Oka

Hironori Kotsubo

Toshiya Noguchi

Muneo Shoji

Yasuhiro Tsutsui

Fumito Uneuchi

Yasunobu Ushiki

Junichi Ando

Risa Tsuruta

Yoichiro Suga

Mai Motono

Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria includingand its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof. 

Hydroxamic acid derivative

Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria includingand its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof: 

A nitrogen-containing heterocyclic compound or pharmaceutically acceptable salt thereof represented by the general formula: which have a potent antibacterial activity and a high safety. Thus, the compounds are useful as antibacterial agents against gram-positive bacteria, gram-negative bacteria and drug resistant bacteria.

Quinolinones and quinoxalinones as antibacterial composition

Quinoxalinones as antibacterial composition

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Toyama, Japan

Yasuko Kawaguchi