Abbott Laboratories Corporation

Kyowa Hakko Kogyo Co., Ltd.

Sagami Chemical Research Center

Yasuki Mori

Moriyuki Sato

Kenichi Mochida

Shinji Tomioka

Takashi Nara

Shigeo Yoshiie

Hideo Matsushima

Kunikatsu Shirahata

Ryo Okachi

Mitsuyoshi Yamamoto

Masahiro Sugimoto

Yoshiaki Shimizu

Kiyosi Kondo

Osamu Terada

Kohei Oshima

The present invention relates to certain novel 4-N-substituted derivatives of the antibiotic Fortimicin B and processes for production thereof. Included in the process aspect of the invention, is a novel method for the semi-synthetic production of the antibiotic Fortimicin C.

Fortimicin B derivatives and process for production thereof

Semisynthetic antibacterial compounds are produced by chemically modifying the antibacterial compound fortimicin A.

Derivatives of fortimicin A

Semisynthetic antibacterial compounds are produced by chemically modifying the antibacterial compound fortimicin B.

Novel derivatives of fortimicin B and process for preparing same

A new biologically active substance, 1-HABA-seldomycin-5, is produced by chemically modifying the antibiotic XK-88-5. The composition of matter is useful as an antibacterial agent.

1-N-Acyl-aminoglycoside-XK-88-5

New 3'-N-demethyl- and 3'-N, 6'-N-didemethyl-1-.alpha.-hydroxy-.omega.-aminoacyl derivatives of the antibiotic XK-62-2, their pharmaceutically-acceptable acid addition salts, and a process for preparing the same are disclosed.

Derivatives of an antibiotic XK-62-2 and process for the production

A new compound which is useful as an antibacterial agent or a synthetic intermediate thereof and has the general formula: ##STR1## (wherein R is hydrogen, benzyloxycarbonyl or t-butyloxycarbonyl) is produced by reacting the compound XK-88-5 with an urethane-type amino-protecting reagent.

Derivatives of XK-88-5 and process for the production thereof

6'-N-methylfortimicin D and 6'-N-methylfortimicin KE are produced by chemically moidifying fortimicin KE. 6'-N-methylfortimicin D is useful as an antibacterial compound; and 6'-N-methylfortimicin KE is useful as an intermediate in the synthesis of the former compound.

Fortimicin derivatives and method for production thereof

A new antibiotic, 2'-deamino-3'-epiamino-3'-deoxy-XK-88-5 represented by the formula: ##STR1## is produced by chemically modifying the antibiotic XK-88-5 represented by the formula: ##STR2##

2'-Deamino-3'-epiamino-3'-deoxy-XK-88-5 and process for the production

1-N-(.alpha.-Hydroxy-.beta.-aminopropionyl) XK-62-2 is produced by chemically modifying the antibiotic XK-62-2 to introduce an .beta.-hydroxy-.beta.-aminopropionyl group to the amino group bonded to the carbon atom at the 1-position. The derivative is useful as an antibacterial agent.

1-N-(.alpha.-Hydroxy-.beta.-aminopropionyl) XK-62-2 and method of

Derivatives of an antibiotic XK-62-2

A new antibiotic, Fortimicin C, is produced by fermentation of a microorganism belonging to the genus Micromonospora. The antibiotic is accumulated in the culture medium and is isolated therefrom.

Fortimicin C and process for production thereof

New derivatives of an antibiotic XK-62-2 are produced by chemically modifying the antibiotic XK-62-2. The new derivatives are 1-N-(.alpha.-hydroxy-.delta.-aminovaleryl)XK-62-2 and 1-N-(.alpha.-hydroxy-.epsilon.-aminocaproyl)XK-62-2 as well as acid addition salts thereof.

Derivatives of an antibiotic XK-62-2 and the process for the production

1-N-[L-(-)-.alpha.-hydroxy-.gamma.-aminobutyryl]XK-62-2 is produced by chemically modifying the antibiotic XK-62-2.

Growing community of inventors

Kawasaki, Japan

Yasuki Mori