Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kirin Co., Limited

Techno Network Shikoku Co., Ltd.

Yasuki Kato

Kunio Ito

Hiroko Kusano

Masahiro Yamauchi

Shiro Akinaga

Hideki Morita

Makoto Kigoshi

Yuji Kawaguchi

Takeshi Iwata

Takaaki Uochi

Jun Sugishita

Setsuko Yano

Motoo Yamasaki

Toshiyuki Suzawa

Hisao Nemoto

Masashi Nakakura

Atsushi Ishihara

Nobuhiro Yagi

Nobuhito Ashikawa

Yutaka Tomoda

Kenji Iwata

Toshihito Hosokawa

Takuya Tokuda

Tsuneaki Tottori

A coated fine particle comprisisng: (i) a complex of a drug and a cationic lipid, wherein (a) the drug is a nucleic acid and the complex is obtained by mixing the drug and the cationic lipid in water, wherein the complex has a diameter of 10 nm to 1,000 nm, and (ii) a lipid layer formed of lipid(s), wherein the lipid(s) is selected from phospholipid, glyceroglycolipid, sphingoglycolipid, cholesterol and synthetic lipid, wherein the complex is coated with the lipid layer.

Fine particles coated with lipid membrane

An object of the present invention is to provide a composition improved in the solubility or oral absorbability. The present invention provides a composition which comprises three components of a slightly water-soluble component, a surfactant and a hydrophilic polymer, and is obtainable by wet granulation in the presence of water.

Composition improved in the solubility or oral absorbability

Objects of the present invention are to provide a compound which is useful as a surface modifier for producing a drug carrier or the like, or a salt thereof; a fine particle comprising the same; and the like. The present invention provides a compound in which a substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, is modified with a glycerol derivative represented by the following formula (1): wherein R represents a residue comprising a reactive group for the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance or for a spacer capable of binding the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, to R-X, or a group capable of being transformed into the reactive group; n represents an integer of 3 or more; and X represents a residue capable of having the following structure by n in number: directly or via the spacer, or a salt thereof; a fine particle comprising the same; and the like.

Compound modified with glycerol derivative

An object of the present invention is to provide a safe, convenient and efficient method for coating fine particles with lipid membrane. There is provided a method for coating fine particles with lipid membrane, characterized in that, the rate of a polar organic solvent in an aqueous solution containing the polar organic solvent where the fine particles are dispersed and lipid is dissolved, is decreased.

Method of coating fine particles with lipid film

The present invention provides a pharmaceutical preparation comprising a compound which can be obtained by reacting a compound having a free amino group with a sugar having the reducing power. The preparation is capable of improving the in vivo durability of various compounds and releasing the compounds in response to changes in pH, and thus is useful for causing the compounds to act specifically on target parts.

Medicinal preparations

An aqueous solution of a pyrazoloacridone compound or pharmaceutical salt is stabilized using an acid, placing the solution in a well-closed container, evacuating air in the container, and sealing the container.

Method of stabilizing aqueous pyrazoloacridone derivative solution

An oil-in-water emulsion containing a xanthine derivative represented by

Fat emulsion containing xanthine derivative

The present inventions provides a liposome preparation characterized by encapsulating indolocarbazole derivatives represented by formula (I): ##STR1## (wherein R represents hydrogen or lower alkyl) into a liposome comprising lipids.

Liposome preparations of indolocarbazole derivatives description

Growing community of inventors

Sunto-gun, Japan

Yasuki Kato