Osaka University

Yasukazu Kanai

Hayato Ikeda

Eku Shimosegawa

Yoshifumi Shirakami

Jun Hatazawa

Tadashi Watabe

Kazuko Kaneda

The invention relates to a method of producing the radiolabeled aryl compound (I) Ar—X, or a salt thereof, wherein X isAt,At,I,I,I, orI. The method involves reacting the aryl boronic acid compound (II) Ar—Y, or a salt thereof, wherein Y is a borono group (—B(OH)) or an ester group thereof, with a radionuclide selected fromAt,At,I,I,I andI, in the presence of an oxidizing agent selected from an alkali metal iodide, an alkali metal bromide, N-bromosuccinimide, N-chlorosuccinimide and hydrogen peroxide, in water.

Production method for radiolabeled aryl compound

The invention relates to a method of producing the radiolabeled aryl compound (I) Ar&#x2014;X, or a salt thereof, wherein X isAt,At,I,I,I, orI. The method involves reacting the aryl boronic acid compound (II) Ar&#x2014;Y, or a salt thereof, wherein Y is a borono group (&#x2014;B(OH)) or an ester group thereof, with a radionuclide selected fromAt,At,I,I,I andI, in the presence of an oxidizing agent selected from an alkali metal iodide, an alkali metal bromide, N-bromosuccinimide, N-chlorosuccinimide and hydrogen peroxide, in water.

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Suita, Japan

Yasukazu Kanai