Meiji Seika Kabushiki Kaisha

Meiji Seika Kaisha, Ltd.

Meiji Seika Kaburhiki Kaisha

Yasukatsu Yuda

Fumiya Hirano

Tomoya Machinami

Takashi Tsuruoka

Seiji Shibahara

Kiyoaki Katano

Fukio Konno

Hiroko Ogino

Tamako Tomomoto

Motohiro Nishio

Shigeharu Inouye

Shigeharu Inoye

Naoki Yamazaki

Kazue Yasufuku

Yuji Matsuhashi

Yamazaki Naoki

A novel benzothiazole or benzimidazole derivative represented by formula (I) ##STR1## wherein X represents a sulfur atom or a NH group; R.sup.1 represents a hydrogen atom, a lower alkoxy group, a chlorine atom, a bromine atom or an iodine atom; R.sup.2 represents a hydrogen atom a substituted or unsubstituted lower alkyl group, a vinyl group, an aryl group or an acyl group; m is an integer of 1, 2 or 3; and n is an integer of 0, 1 or 2, which shows an excellent acid secretion suppressing effect and gastric mucosa protecting effect, and an antiulcer agent containing the same as an active ingredient.

Benzothiazole and benzimidazole derivatives and antiulcer agent

Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which A, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;

Azole derivatives and anti-ulcerative composition containing same

A piperidine compound represented by formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group having from 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4 carbon atoms, a hydroxymethyl group, --CO.sub.2 R.sup.3, or ##STR2## wherein R.sup.3 represents a hydrogen atom or a lower alkyl group having from 1 to 4 carbon atoms; R.sup.4 represents a hydroxyl group, a lower alkoxy group having from 1 to 4 carbon atoms or --NR.sup.6 R.sup.7 (wherein R.sup.6 and R.sup.7, which may be the same or different, each represent a hydrogen atom or a lower alkyl group having from 1 to 4 carbon atoms); and R.sup.5 represents a hydrogen atom, a lower alkanoyl group having from 1 to 4 carbon atoms, or a chlorobenzoyl group; R.sup.2 represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms, a substituted or unsubstituted benzyl group, or a (2,2,6,6-tetramethylpiperidin-1-yl)ethyl group; and n represents 0 or an integer of 1 or 2, and an antiulcer composition containing said piperidine compound.

Piperidine compounds and antiulcer composition containing the same

A thiazole or imidazole derivative having the general formula (I): ##STR1## wherein: R.sup.1 and R.sup.2, which may be the same or different, each independently represent a hydrogen atom, or a phenyl or heteroaryl group, or R.sup.1 and R.sup.2 may together form a benzene ring which may be optionally substituted by a halogen atom or a lower alkyl optionally substituted by a halogen atom, lower alkoxy or nitro group;

Thiazole and imidazole derivatives and antiulcer composition containing

Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which

Thiazolo [4,5-6] pyridine derivatives and anti-ulcerative composition

Growing community of inventors

Yokohama, Japan

Yasukatsu Yuda