Astellas Pharma Gmbh

Yasuhito Nagai

Hiroyuki Koshio

Takafumi Shimizu

Taisuke Takahashi

Norio Asai

Keiko Kawabata

Karl Bruce Thor

Provided is a compound which is useful as an agent for treating or preventing 5-HTreceptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like. The present inventors have investigated compounds having a 5-HTreceptor agonist activity and have found that the benzazepine compounds of the present invention have an excellent 5-HTreceptor agonist activity, thereby completing the present invention. That is, the benzazepine compounds of the present invention have a 5-HTreceptor agonist activity and can be used as an agent for treating or preventing 5-HTreceptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like.

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Tokyo, Japan

Yasuhito Nagai