Chugai Seiyaku Kabushiki Kaisha

Yasuhisa Takeda

Takashi Matsuno

Takashi Mori

Yasushi Murakami

Sakae Takaku

Shigeyuki Kataoka

Hiroshi Suzuki

Minoru Shindo

Yasuhiro Yamashita

Yoshimitsu Iida

Hiroharu Matsuoka

Haruki Ogawa

Masahiko Mihara

Koji Mizuno

Hiroshi Okazaki

Tamotsu Yamazaki

Kazuo Igusa

Toshichika Ogasawara

Shun-Ichi Hata

Kenichi Akamatsu

Nobuaki Kato

Yoshiyuki Ohsugi

Shigeru Takanashi

Tsutomu Kawaguchi

Shin Shimaoka

Nobuhiro Ohi

Yutaka Sugawara

Akira Okazaki

Hiroki Mitsui

Mitsuaki Handa

Keiichiro Tsuji

Fumiaki Matsuura

Yumiko Takeda

Shinichi Kaiho

Hisako Masuda

Mihoko Ohtaka

Akiko Ariga

Katushito Miyamoto

Hiromichi Nishina

Methotrexate derivative

1,4,5,6-Tetrahydronicotinamide derivative represented by the formula: ##STR1## (wherein R is defined in the specification), a process of preparing the same and pharmaceutical composition containing the same are disclosed. The compound has action for suppressing aggregation of platelets, and antiinflammatory, antipyretic and analgesic actions.

Tetrahydronicotinamide derivative, pharmaceutical compositions and use

An anti-tumor preparation containing cells of Streptococcus equisimilis and a process for preparing the preparation which comprises subjecting the cells to heat treatment in a salt solution with or without penicillin treatment.

Anti-tumor preparation against certain tumors and process for preparing

A terephthalic acid monoamide derivative of the formula: ##STR1## (wherein R is a straight- or branched-chain lower alkyl group; R' and R' may be the same or different, and represent a hydrogen atom, or a straight- or branched-chain lower alkyl group) or pharmaceutically acceptable salts thereof are disclosed. A process for preparing such terephthalic acid monoamide derivative or its salts, as well as an anti-allergic agent containing such derivative or its salts as an effective ingredient are also disclosed.

Terephthalic acid monoamide derivatives, process for preparing the same,

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Yokohama, Japan

Yasuhisa Takeda