Research Development Corporation of Japan

Other

Kao Corporation

Nippon Kayaku Kabushiki Kaisha

Japan Science and Technology Corporation

Nippon Oil Fats Co., Ltd.

K. K. Vayu

Tokyo Women's Medical College

Amersham Pharmacia Biotech K.k.

Yasuhisa Sakurai

Kazunori Kataoka

Masayuki Yokoyama

Yukio Nagasaki

Teruo Okano

Masao Kato

Noriko Yamada

Naoya Ogata

Shohei Inoue

Akihiko Kikuchi

Hideko Kanazawa

Kohei Sanui

Nobuhiko Yui

Yoshikazu Matsushima

Nobuyuki Ohsako

Kazuya Okamoto

Yoshishige Murata

Shigeto Fukushima

Takayuki Amiya

Shigeru Kitano

Tsuyoshi Miyazaki

Kazuhisa Shimizu

Akira Mamada

Teiji Tsuruta

Hiroko Mashiba

Yoshiyuki Koyama

Ryuji Uehara

Kazuhiko Nojima

Ken Suzuki

Hotaka Ito

Tomoko Akutsu

Megumi Machida

Kazunori Waki

Daijiro Shiino

To provide chromatographic packings whereby biological components, etc. which cannot be separated by either ion-exchange chromatography or reversed phase chromatography employed alone can be efficiently separated without deteriorating their activities. Use is made of a packing which contains a charged copolymer and makes it possible to change the effective charge density on the surface of a stationary phase by a physical stimulus while fixing a mobile phase to an aqueous system.

Packing material for chromatography having novel characteristic and method for isolation of substance using the same

PTH-amino acids can be analyzed within a short time at a high sensitivity by chromatographically separating said PTH-amino acids with the use of a packing wherein the hydrophilic/hydrophobic balance on the stationary phase surface can be changed by an external signal while fixing the mobile phase to an aqueous system.

Method for separating PTH amino acids

Modified polymers containing a poly(2-hydroxyethyl(meth)acrylate) chain as the hydrophilic polymer segment in which a hydrophobic polymer chain or a lipid residue of a sterol is bound to either end of the poly(2-hydroxyethyl(meth)acrylate) chain through a covalent bond or in which the poly(2-hydroxyethyl(meth)acrylate) chain is grafted onto the backbone chain at either end thereof. These modified polymers are excellent in compatibility with liquid or a living body, thus being advantageously usable particularly in medical fields.

Modified polymers containing poly(2-hydroxyethyl(meth)acrylate segment in the molecule

Anthracycline compound derivative and pharmaceutical preparation

This invention is a water-soluble high molecular polymerized drug comprising a water-soluble clock copolymer having a hydrophilic segment and a hydrophobic pharmacological-functioning segment to side chain of which a drug is bonded. The hydrophilic first segments of the present invention include polyethylene glycol, polysaccharides, polyacrylamide, and so on. The hydrophobic segments being attached to a drug include polyaspartic acid, polyglutamic acid, polylysine, or derivatives thereof. Drugs to be attached to the hydrophobic segment include anti-cancer drugs, drugs for central nerve, drugs for circulatory organs, and so on.

Water soluble high molecular weight polymerized drug preparation

The present invention relates to a bifunctional polyether having groups different from each other at both ends, with a polymerization degree of 5 to 10000 and consisting of repeating units each represented by the following formula (I): ##STR1## (wherein R.sub.1, represents a hydrogen atom, halogen atom, or a lower alkyl group optionally substituted by a halogen atom, and R.sub.1 in each repeating unit may be the same or different), as well as to a process for the preparation thereof and a polymerization initiator therefor. The process of production and polymerization initiator of the present invention enable 100% introduction of a primary amino group into one of the ends of polyether.

Polyether having heterofunctional groups at both ends, process for the

The present invention relates to drug carriers composed of a block copolymer having hydrophilic and hydrophobic segments, a polymeric micelle type drug comprising hydrophobic drugs trapped by physical treatments in said drug carrier and methods for trapping hydrophobic drugs in the drug carrier. The drugs carrier composed of the block copolymer according to the invention forms a stable polymeric micelle structure with which hydrophobic drugs can be incorporated very efficiently via physical trapping. It was found that the incorporated drug is stably maintained in micelles even in the presence of serum. In addition, a drug difficult to administer into the living body owing to sparing water-solubility for its high hydrophobicity can be administered in the form of polymeric micelle drug.

Physical trapping type polymeric micelle drug preparation

The present invention provides a polymer complex of a sugar response type having boronic acid groups in the polymer. Medicines may be contained or linked, preferably, the medicines have hydroxy groups. The polymer having boronic acid groups and the medicine having hydroxy groups may be linked by boronic acid ester bonds. The complex may also comprises polymers having boronic acid groups and polymers having hydroxy groups, and these polymers may be cross-linked.

Polymers having benzeneboronic acid groups and insulin complexes of same

Disclosed is a bed material whereby cultured or grown cells are collected or detached from the material without a proteolysis enzyme or chemical material. The bed material comprises a support and a coating thereon, wherein the coating is formed from a polymer or copolymer which has a critical solution temperature to water within the range of 0.degree. C. to 80.degree. C.

Bed material for cell culture

An antithrombogenic synthetic polymer has repeat structural units represented by the following structural formula consisting of portions I and II: ##STR1## a microdomain structure composed of crystalline phases and amorphous phases, each phase having an average size of 5 to 10 nm, and a molecular weight in the range of about 10,000 to about 300,000. The polymer exhibits little adhesion of blood platelets thereto, an excellent antithrombogenic property and a sufficient mechanical strength.

Antithrombogenic synthetic polymer and process for its preparation

Antithrombogenic synthetic elastomer having repeat units comprising portion I which is a soft segment unit containing a polyether and portion II which is a hard segment unit: ##STR1## R is a straight-chain or branched-chain alkylene group containing 2 to 4 carbon atoms, R' is amide a urethane, an urea, n ranges up to 180, m is an integer of 1 to 20, l is an integer of 1 to 10, said polymer having a microdomain structure composed of soft and hard segments, the domains of which have an average size of 10 to 20 nm, and a molecular weight of about 80,000 to about 500,000. The polymer shows little adhesion of blood platelets thereto, little deformation of adhering blood platelets and an excellent antithrombogenic property. This polymer has excellent mechanical properties as an elastomer. This polymer is useful for artificial organs such as blood vessels, kidneys, hearts, and for functional biomaterials and devices such as absorbents for biological components, carriers for sustained release preparations, adhesive materials for living tissue, injectors, blood bags and catheters.

Antithrombogenic synthetic elastomer and process of preparation thereof

Growing community of inventors

Tokyo, Japan

Yasuhisa Sakurai