Sumitomo Rubber Industries Limited

Yamagata University

Kyushu University

Osaka University

Yasuhisa Minagawa

Masaru Tanaka

Takashi Hoshiba

Tomokazu Shibuya

Noriko Yagi

Haruka Emura

Kiyoshige Muraoka

Kazuo Hochi

Tetsuo Mizoguchi

Atsushi Takahara

Takefumi Nakashita

Yasuhiko Kondo

Motoyasu Kobayashi

Shunsuke Kosaka

Kazuki Suto

Mitsuko Takii

Takayuki Hattori

Toshiaki Sakaki

Kiyoshi Ueyoko

Naohiko Kikuchi

Hirofumi Yamamoto

Ryoji Kojima

Yutaka Kuroda

Sadahiko Matsumura

Tatsuya Kubo

Ai Matsuura

Masaki Mori

Michio Hirayama

Fumiya Chujo

Noboru Wakabayashi

Keiji Tanaka

Yasumasa Bito

Masatoshi Kobayashi

Kentaro Fujimoto

Hiroki Sarashi

Minoru Ueda

Naotsugu Haraguchi

Hisao Matsuno

Toyoaki Hirata

Chujo Fumiya

Mitsuho Takii

Provided are a polymer-coated substrate in which a polymer layer formed on the surface of a substrate is stable for a long period of time even in a liquid environment, and a medical analysis device including the polymer-coated substrate. Included is a polymer-coated substrate which includes a substrate, a silane compound layer formed on a surface of the substrate, and a polymer layer formed on the silane compound layer.

Polymer-coated substrate and medical analysis device

Provided are hydrophilic substrates provided with a hydrophilic polymer layer having controlled surface uniformity and irregularities, and methods for preparing the hydrophilic substrates. Included are hydrophilic substrates including a substrate having a surface containing at least one group represented by —N(R)or —N(R)wherein each Ror Ris the same or different and represents a hydrogen atom or a substituted or unsubstituted hydrocarbon group optionally containing a hetero atom; and a hydrophilic polymer layer provided on the surface of the substrate.

Hydrophilic substrate and method for preparing hydrophilic substrate

The present invention provides a medical analysis device and a cell analysis method, which can capture specific cells such as many types of cancer cells including cancer cells not expressing EpCAM and stem cells. Provided is a medical analysis device including a well portion, the well portion having a hydrophilic silane compound layer formed at least partly on the inner surface thereof.

Medical analysis device and cell analysis method

Provided are specific cell-fractionating and -capturing methods which can fractionate and capture, respectively, specific cells (e.g., many types of cancer cells, including cancer cells not expressing EpCAM, or peripheral blood stem cells). Included is a method for fractionating specific cells present in blood or biological fluid, the method including fractionating the blood or biological fluid by centrifugation to collect the specific cells in the blood or biological fluid, the centrifugation being carried out using a container having a low protein adsorbing layer at least partially formed on the inner surface thereof.

Specific cell fractionating and capturing methods

The present invention provides a method for capturing specific cells (e.g. many types of cancer cells, including cancer cells not expressing EpCAM), and a method for analysis of specific cells involving the method. Included is a method for capturing specific cells present in blood or biological fluid, the method including: agglutinating blood cells in sampled blood or biological fluid; centrifuging the resulting blood or biological fluid; and then capturing specific cells therefrom onto a hydrophilic polymer layer.

Method for capturing specific cells

An object of the present disclosure is to provide a new sulfur-based positive-electrode active material which can improve cyclability of a lithium-ion secondary battery while maintaining a charging and discharging capacity, a positive-electrode comprising the positive-electrode active material, and a lithium-ion secondary battery comprising the positive-electrode. The sulfur-based positive-electrode active material is one comprising doped nitrogen atoms obtainable by heat-treating a starting material comprising a chain organic compound and sulfur under an atmosphere of a nitrogen atom-doping gas.

Sulfur-based positive-electrode active material, positive-electrode and lithium-ion secondary battery

The present invention provides a medical analysis device and a cell analysis method with which it is possible to count the number of cancer cells, culture the cancer cells, and determine the effect of drugs on the cancer cells. The present invention relates to a medical analysis device intended to capture cancer cells, the medical analysis device having multiple wells.

The present invention provides a method for capturing specific cells (e.g. many types of cancer cells, including cancer cells not expressing EpCAM) and a method for analysis of specific cells involving the method. Included is a method for capturing specific cells present in blood or biological fluid, the method including: subjecting sampled blood or biological fluid to enrichment; and capturing specific cells therefrom onto a hydrophilic polymer layer in a flow field.

A simulation method for analyzing a breakage of a molecular chain of a polymer material using a computer comprises: defining a polymeric material model by setting a molecular chain model in a virtual space corresponding to a portion of the polymeric material; and calculating a breaking of the molecular chain model. The calculating of the breaking comprises: a step Sof performing a molecular mechanics calculation using the polymeric material model; a step Sof performing a quantum mechanics calculation targeting on only a subset model including a particle model couple whose distance is greater than a predetermined first distance; and a step Sof dissociating the bond between the particle models in the molecular chain model which particle models correspond to the particle model couple, if the distance between the particle models is larger than a second distance, wherein the second distance is larger than the first distance and equal to a distance between the particle models at an inflection point of a bond-dissociation potential plus a value of from 1.0 to 2.5 angstrom.

Simulation method for polymer material

The present invention provides a hydrophilic substrate including a hydrophilic polymer layer having a smooth surface and formed of a special polymer (hydrophilic polymer). Included is a hydrophilic substrate including on its surface a hydrophilic polymer layer formed of a hydrophilic polymer having a number average molecular weight of 40,000 or more.

Hydrophilic substrate

Provided are methods for surface-modifying a rubber vulcanizate and surface-modified elastic bodies, which can cost-effectively provide a variety of functions, including sliding properties, liquid leakage resistance, and protein adsorption resistance. Included is a method for surface-modifying a rubber vulcanizate as a modification target, the method including: step 1 of forming polymerization initiation points A on the surface of the modification target; step 2 of radically polymerizing a monomer starting from the polymerization initiation points A to grow polymer chains; and step 3 of adding a silane compound to the surfaces of the polymer chains, followed by reaction with at least a fluoroalkyl group-containing silane compound to form modified polymer chains.

Surface modification method and surface-modified elastic body

The present invention provides a medical analysis device and a cell analysis method, which can capture many types of cancer cells, including cancer cells not expressing EpCAM. The present invention relates to a medical analysis device having a well portion, the well portion having a hydrophilic polymer layer formed at least partly on the inner surface thereof, the hydrophilic polymer layer having fibronectin adsorbed thereto.

The present invention provides surface-modified metals such as metal medical devices, e.g., guide wires, syringe needles, and metal tubes in medical devices or equipment, in which a lubricant layer is firmly bonded to the surface to impart lubricity to the surface, and further to improve the durability of the lubricant layer on the surface, thereby reducing deterioration of sliding properties, as well as methods for modifying a metal surface. The present invention relates to a surface-modified metal having a surface at least partially treated by polymerizing a monomer in the presence of a hydrogen abstraction type photopolymerization initiator.

Surface-modified metal and method for modifying metal surface

Provided are a medical analysis device and a cell analysis method which can capture many cancer cells, including cancer cells not expressing EpCAM. The medical analysis device includes a flow channel zone, and also includes a chamber zone. The inner surface of the flow channel zone is at least partially provided with a layer of a hydrophilic polymer having a thickness of 2 to 200 nm.

Methods are provided for surface-modifying a rubber vulcanizate or a thermoplastic elastomer. The methods allow these rubber vulcanizate or thermoplastic elastomer objects to have a lubricating surface layer chemically fixed thereon, instead of having a resin coating which has drawbacks such as a reduction in lubricity due to e.g. separation or peeling of the coating during movement within a vessel or tract. The present invention relates to a method for surface-modifying an object made of a rubber vulcanizate or a thermoplastic elastomer, the method including: step 1 of forming polymerization initiation points on a surface of the object; and step 2 of radically polymerizing a monomer starting from the polymerization initiation points by irradiation with ultraviolet light having a wavelength of 300 to 400 nm in the presence of an alkali metal salt to grow polymer chains on the surface of the object.

Growing community of inventors

Kobe, Japan

Yasuhisa Minagawa