Takasago International Corporation

Yasuhiro Uozumi

Hidenori Kumobayashi

Kenzo Sumi

Heiko Hoche

Akiko Yamazaki

Tamio Hayashi

A polymer-carrying optically active binaphthyl type oxazoline compound having axial asymmetry, represented by the following general formula (1) (wherein Rand Rmay be the same or different from each other and each represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or the like; Ris a hydrogen atom or &#x2014;R&#x2014;X&#x2014;R; Ris a hydrogen atom or the like; Ris a straight- or branched-chain aliphatic hydrocarbon chain which may have a directly or indirectly bonded substituent; X is CH, CO, O, CONRor NR; Ris a directly or indirectly bonded polymer; and Ris a hydrogen atom or the like), and to a transition metal complex which uses the compound as the ligand.

Polymer-carrying optically active binaphthyl type oxazoline compound

A phosphine compound represented by formula (I): ##STR1## wherein Ph represents a phenyl group; and R represents a lower alkyl group or --OR.sup.1, wherein R.sup.1 represents a hydrogen atom, a cycloalkyl group having from 5 to 7 carbon atoms, or an alkyl group having from 1 to 6 carbon atoms which may be substituted with a halogen atom, a lower alkoxy group, a lower alkoxy group-substituted lower alkoxy group, or a phenyl group, and a transition metal complex using the phosphine compound (I) as a ligand are disclosed. The transition metal complex, when used as a catalyst for various enantioselective synthesis reactions, e.g., enantioselective silylation reaction, provides a desired product in high yield at high optical purity. The absolute configuration of the product can be arbitrarily selected by selecting the optical isomer of the ligand in the transition metal complex catalyst.

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Nagoya, Japan

Yasuhiro Uozumi