Taisho Pharmaceutical Co., Ltd.

Toyama Chemical Co., Ltd.

Yasuhiro Tsutsui

Fumihito Ushiyama

Tadashi Tanaka

Taro Kiyoto

Hiroki Urabe

Toshiya Noguchi

Junichi Ando

Yasunobu Ushiki

Yasuko Kawaguchi

Hiromasa Horikiri

Mai Motono

Mai Yokotani

Toru Yamaguchi

Naoya Ono

Tetsuya Tanikawa

Risa Tsuruta

Noritomo Fujino

Keiko Yamamoto

Ayumu Mori

An amidine compound represented by formula (I) (wherein Arepresents a nitrogen atom or a group represented by formula CR; Aand Aare the same as or different from each other and independently represent a nitrogen atom or a group represented by formula CH; Rrepresents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; Rand Rare the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a Calkyl group, a Chaloalkyl group or a Calkoxy group; and Rand Rare the same as or different from each other and independently represent a hydrogen atom, a Chaloalkyl group, a Calkyl group or the like) or a salt thereof. The compound is useful as an anti-fungal agent.

Amidine compound or salt thereof

A nitrogen-containing heterocyclic compound or pharmaceutically acceptable salt thereof represented by the general formula: which have a potent antibacterial activity and a high safety. Thus, the compounds are useful as antibacterial agents against gram-positive bacteria, gram-negative bacteria and drug resistant bacteria.

Quinolinones and quinoxalinones as antibacterial composition

Disclosed is a compound represented by the general formula: wherein Rrepresents an aryl or heterocyclic group which may be substituted or the like; Xrepresents a C-Calkylene group or the like; X, Xand Xindependently represent NH, a bond or the like; Xrepresents a lower alkylene group, a bond or the like; Yrepresents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z, Z, Z, Z, Zand Zindependently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z, Z, Zand Zrepresents a nitrogen atom, or a salt thereof, which is useful as an antibacterial agent.

Heterocyclic compound or salt thereof and intermediate thereof

Quinoxalinones as antibacterial composition

Disclosed is a compound represented by the general formula: [wherein Rrepresents an aryl or heterocyclic group which may be substituted or the like; Xrepresents a C-Calkylene group or the like; X, Xand Xindependently represent NH, a bond or the like; Xrepresents a lower alkylene group, a bond or the like; Yrepresents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z, Z, Z, Z, Zand Zindependently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z, Z, Zand Zrepresents a nitrogen atom] or a salt thereof, which is useful as an antibacterial agent.

Growing community of inventors

Toyama, Japan

Yasuhiro Tsutsui