Teijin Limited

Yasuhiro Takano

Kazuya Takenouchi

Kenji Manabe

Seiichi Ishizuka

Qingzhi Gao

Ryo Sogawa

Hideki Horiuchi

Tomohiro Ohta

Takashi Kamimura

Tatsuki Shiota

Shigehisa Kitahara

Mikio Ota

Shiro Kondo

Fuminori Miyagi

This invention provides remedies or prophylactics for diseases in association with chemokines such as MIP-1 &#x3b1; and/or MCP-1. Namely, remedies or prophylactics for diseases in association with the chemokines such as rheumatoid arthritis or nephritis contain, as the active ingredient, cyclic amine derivatives represented by the following formula (I), pharmaceutically acceptable acid addition salts thereof or pharmaceutically acceptable C-Calkyl addition salts thereof.

Remedies or prophylactics for diseases in association with chemokines

Compounds expressed by the following general formula (1),[wherein, Rand Rare each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1), (1-2), (1-3), (1-4) and (1-5)].The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.

Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same

Compounds expressed by the following general formula (1),[wherein, Rand Rare each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1) to (1-5)].The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.

Vitamin D, derivatives and remedies for inflammatory respiratory diseases containing the same

Protecting agent for organ or tissue

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Tokyo, Japan

Yasuhiro Takano