Chugai Seiyaku Kabushiki Kaisha

Yasuhiro Sugamata

Masayuki Tsuchiya

Toshihiko Ohtomo

Kunihiro Matsumoto

Revealed are that the actions of inflammatory cytokine and the production of inflammatory cytokines such as IL-1 and TNF induced by an inflammatory stimulus as well as the production of other inflammatory cytokines such as IL-6 induced by the former class of inflammatory cytokines are all suppressed by inhibiting the signal transduction through TAK1.

Methods of screening compounds inhibiting signal transduction through inflammatory cytokines

The present invention relates to methods of screening for compounds that inhibit signal transduction by inflammatory cytokines. The methods include providing a sample that contains a TAK1 and a TAB1; contacting the sample with a compound; detecting binding between the TAK1 and the TAB1; and selecting the compound if binding between the TAK1 and TAB1 is inhibited in the sample compared to a control.

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Shizuoka, Japan

Yasuhiro Sugamata