Otsuka Pharmaceutical Factory, Inc.

Yasuhiro Sakai

Yoshihiko Tsuda

Kazuyoshi Miyata

Yasuhide Inoue

Shinya Miki

Norihiro Yoshinaga

Yasuo Shoji

Masako Doi

Akifumi Hagi

Yasuhisa Kurogi

Keigo Sato

Seiichirou Kanou

Takahiro Tomoyasu

Kenichi Kawamura

Akiyoshi Kuroda

The present invention provides a phosphonic acid diester compound represented by General Formula wherein R, R, Rand Rare the same or different, and represent hydrogen, halogen, lower alkyl or lower alkoxy; Ris phenyl having on the phenyl ring 1&#x2013;3 substituents selected from the group consisting of lower alkyl, halogen-substituted lower alkyl, lower alkoxy, halogen-substituted lower alkoxy, phenoxy, benzyloxy, hydroxyl, halogen, nitro, lower alkylthio, di(lower alkyl)amino, lower alkanolyamino, pyrrolidinyl and phenyl, or the like, provided that Ris not mono(lower alkoxy)pheny; and Ris lower alkyl;and an ACAT-1 inhibitor containing the compound as an active ingredient.

Phosphonic diester derivatives

Phosphonic acid diester derivatives

Process for preparing quinazolin-4-one derivatives

Growing community of inventors

Nerima-ku, Japan

Yasuhiro Sakai