Kaneka Corporation

Yasuhiro Saka

Nobuo Nagashima

Yasuyoshi Ueda

Tadashi Moroshima

Yoshihide Fuse

Koichi Kinoshita

Kazumi Okuro

Akio Fujii

Kenji Inoue

Masanobu Sugawara

Kenji Fujii

Akira Nishiyama

Toshihiro Takeda

Tatsuya Honda

Kazunori Hosoe

Masaru Mitsuda

Yoshifumi Yanagida

Katsuji Yamashita

Takehiko Yamane

Shinichi Sakashita

The objective of the present invention is to provide an optically active imidazolidinone derivative widely usable for synthesizing an optically active amino acid, a method of easily producing the derivative, and a method of easily producing an optically active amino acid by using the derivative. The objective can be achieved by producing an optically active amino acid using a novel optically active imidazolidinone derivative represented by a general formula (3) and the like. According to the method of the present invention, an optically active imidazolidinone derivative can be obtained by preferential crystallization from a mixture of isomers of the imidazolidinone derivative. Therefore, an optically active amino acid can be easily and stereoselectively produced without cumbersome procedures required for the conventional methods, such as resolution of diastereomers, synthesis from an optically active amino acid and resolution of isomers by silica gel column chromatography.

Imidazolidinone derivative, method of producing the same and method of producing optically active amino acid

An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.

Process for producing optically active amino acid derivatives

Process for cyclizing optically active 4-amino-2-halogenobutyric acids

Process for preparing optically active amino acid derivatives

Process for the preparation of 3-hydroxytetrahydrofuran

A method for treating a digestive organ disease caused by the infection of Helicobacter, comprising administering a rifamycin derivative expressed by the formula (I), or a physiologically acceptable salt thereof ##STR1##

Treatment of disease caused by infection of Helicobacter

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Hyogo, Japan

Yasuhiro Saka