Toray Industries, Inc.

Yasuhiro Morita

Naoki Izumimoto

Katsuhiko Iseki

Shunsuke Iwano

Shuji Udagawa

Tomoya Miyoshi

Tadamasa Arai

Yuji Osada

Kei Takahashi

Yuji Sugawara

Motohiro Shiraki

Chihiro Yoshida

Hirozumi Takahashi

Hidetoshi Noda

Tetsuro Koreeda

Masanori Murakami

Yoko Baba

Keiyu Oshida

Hideyuki Tsutsui

Eriko Higashi

Hideyuki Tsutsiu

A crystal of ethane disulfonate of (S)-1-(4-(dimethylamino)piperidin-1-yl)-3-hydroxy-3-(1-methyl-1H-imidazol-2-yl)propan-1-one, having peaks at diffraction angles 2&#x3b8;)(&#xb0; of 12.6&#xb1;0.2, 16.0&#xb1;0.2, 17.7&#xb1;0.2, 18.5&#xb1;0.2, and 21.3&#xb1;0.2 in powder X-ray diffraction; and the crystal of ethane disulfonate of (S)-1-(4-(dimethylamino)piperi din-1-yl)-3-hydroxy-3-(1-methyl-1H-imidazol-2-yl)propan-1-one, having an endothermic peak at 173&#xb0; C. to 177&#xb0; C. in simultaneous thermogravimetric-differential thermal analysis.

Crystals of cyclic amine derivative and pharmaceutical use thereof

Crystals of a compound that exhibits an analgesic action against neuropathic pain and/or fibromyalgia syndrome are useful as pharmaceuticals. The crystals may be of (S)-1-(4-(dimethylamino)piperidin-1-yl)-3-hydroxy-3-(1-methyl-1H-imidazol-2-yl)propan-1-one or a pharmacologically acceptable salt thereof.

A cyclic amine derivative represented by a general formula (I) or a pharmacologically acceptable salt thereof: wherein n represents 1 or 3, Rrepresents an alkyl group having 1 to 6 carbon atoms unsubstituted, substituted with a halogen atom or substituted with an alkyloxy group having 1 to 4 carbon atoms and Rrepresents a hydrogen atom or a halogen atom.

Cyclic amine derivative and pharmaceutical use thereof

A compound exerts an analgesic effect against pain, in particular, neuropathic pain and/or fibromyalgia syndrome. A cyclic amine derivative represented by the following general formula, or a pharmacologically acceptable salt thereof:  Methods using the compound including the cyclic amine derivative or a pharmacologically acceptable salt thereof to treat pain, neuropathic pain and fibromyalgia syndrome.

A compound exerts a strong analgesic effect against pain, in particular, neuropathic pain and/or fibromyalgia syndrome. A cyclic amine derivative represented by general formula or a pharmacologically acceptable salt thereof:  A method of treating neuropathic pain includes administering a therapeutically effective amount of the cyclic amine derivative to a mammal. A method of treating fibromyalgia syndrome includes administering a therapeutically effective amount of the cyclic amine derivative to a mammal.

A compound exerts a strong analgesic effect against pain, in particular, neuropathic pain and/or fibromyalgia syndrome. The cyclic amine derivative is represented by formula, a prodrug thereof or a pharmacologically acceptable salt thereof: wherein A represents a group represented by Formula (IIa), (IIb) or (IIc): wherein

A method relieves both nociceptive pain and neuropathic pain and has fewer side effects. The compound includes cyclohexane derivatives represented by the following compound, or pharmaceutically acceptable salts thereof or prodrugs thereof. 

Cyclohexane derivative and pharmaceutical use thereof

A compound has a strong analgesic action against both nociceptive pain and neuropathic pain and has less side effects, and is medically useful. The compound includes cyclohexane derivatives represented by the following compound, or pharmaceutically acceptable salts thereof or prodrugs thereof. 

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Kamakura, Japan

Yasuhiro Morita