National Institute of Advanced Industrial Science and Technology

Yasuhiro Mie

Sakae Tsuda

Yasuo Komatsu

Yoshiyuki Nishimiya

Fumio Mizutani

Yu Hirano

A nucleic acid complex includes a single-stranded nucleic acid and a cross-linked double-stranded nucleic acid including the first nucleic acid strand linked to at least one of the 5' end and the 3′ end of the single-stranded nucleic acid and the second nucleic acid strand including a base sequence that is completely or sufficiently complementary to the first nucleic acid strand.

Nucleic acid complex, method for forming nucleic acid hybridization, pharmaceutical composition, nucleic acid probe, and complementary-strand nucleic acid complex

A novel material having ice nucleation activity or activity to promote freezing is provided. The present invention related to a carrier upon which polypeptides are immobilized for promoting the freezing of water or a hydrous substance. That is a carrier upon which polypeptides having side chains for binding to water molecules on the molecular surfaces of the polypeptides are integrated and immobilized; and a carrier upon which antifreeze proteins are integrated and immobilized.

Growing community of inventors

Hokkaido, Japan

Yasuhiro Mie