Lederle (Japan), Ltd.

Yasuhiro Kuramoto

Toshio Kumagai

Satoshi Tamai

Yoshimitsu Nagao

Hisashi Shimidzu

Sakae Aoyagi

Takaaki Hayashi

A method of deprotection which comprises reacting a compound having at least one of amino, hydroxyl, mercapto and carboxyl groups protected by a substituted or unsubstituted benzyloxycarbonyl group or by a substituted or unsubstituted benzyl group with zinc in a buffer, thereby splitting off the protective benzyloxycarbonyl or benzyl group.

Method of eliminating protective groups

An azetidin-2-one derivative represented by the following formula (I) ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group, an aryl group, an aralkyl group, a lower alkoxy group, aralkoxy group, a lower alkylthio group, an aralkylthio group, or a substituted amino group, R.sup.2 represents a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, and R.sup.3 represents a hydrogen atom or a group of the formula ##STR2## in which R.sup.4 represents a hydrogen atom or a protective group for the hydroxyl group; and a process for production thereof.

Azetidin-2-one derivatives, and process for production thereof using tin

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Niiza, Japan

Yasuhiro Kuramoto