Takeda Pharmaceutical Company Limited

Yasuhiro Imaeda

Hidekazu Tokuhara

Takanobu Kuroita

Masahiro Ito

Yasuyoshi Arikawa

Hironobu Maezaki

Kouichi Iwanaga

Naohiro Taya

Akinori Toita

Hironori Kokubo

Keiji Kubo

Koji Ono

Hideyuki Sugiyama

Toshio Tanaka

Takuto Kojima

Hiroshi Banno

Tomohiro Okawa

Minoru Sasaki

Keiko Kakegawa

Yoshiyuki Fukase

Yasutomi Asano

Takaharu Hirayama

Tohru Miyazaki

Ayumu Sato

Jinichi Yonemori

Yasuhiro Hirata

Fumiaki Kikuchi

Nobuki Sakauchi

Misaki Homma

Nobuo Cho

Ryo Mizojiri

Douglas Robert Cary

Moriteru Asano

Jun Fujimoto

Osamu Kubo

Nao Morishita

Takeshi Yamamoto

Masato Yoshikawa

Shinkichi Suzuki

Zenichi Ikeda

Shinobu Sasaki

Michiko Tawada

Takeshi Yasui

Shiinobu Sasaki

Hirotaka Kamitani

Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I):

Nitrogen containing heterocycles as CDK12 inhibitors

The present invention provides a heterocyclic compound having a HDAC inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof.

Heterocyclic compound

Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of central nervous system diseases including neurodegenerative disease, and the like, and a medicament comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

HDAC6 inhibitory heterocyclic compound

Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.

Heterocyclic compound and use thereof

The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I): wherein Rrepresents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, Xrepresents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Yrepresents &#x2014;C(O)&#x2014;, &#x2014;S(O)&#x2014; or &#x2014;S(O)&#x2014;, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, Xrepresents a bond or an optionally substituted lower alkylene, Yrepresents &#x2014;C(O)&#x2014;, &#x2014;S(O)&#x2014;, &#x2014;S(O)&#x2014; or &#x2014;C(&#x2550;NR)&#x2014;, Xrepresents an optionally substituted Calkylene or an optionally substituted Calkenylene, Zrepresents &#x2014;N(R)&#x2014;, &#x2014;O&#x2014; or a bond, Zrepresents &#x2014;C(R) (R)&#x2014;, &#x2014;N(R)&#x2014;, etc., and Zrepresents &#x2014;C(R)(R)&#x2014;, &#x2014;N(R)&#x2014;, etc., or a salt thereof.

Cyclic amide derivative, and its production and use

Compounds represented by the formulas (I) (II) wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like. 

A renin inhibitor comprising a compound represented by the formula: wherein each symbol is as defined in the description, or a salt thereof or a prodrug thereof. The compound of the present invention has a superior renin inhibitory activity, and thus is useful as an agent for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.

Amide compounds and use of the same

The present invention provides a urea derivative or a salt thereof, which is useful as a therapeutic agent for thrombosis. The derivative is represented by Formula (I): wherein Cy is an aromatic hydrocarbon group which may be substituted or an aromatic heterocyclic group which may be substituted; Ris a hydrogen atom or a hydrocarbon group which may be substituted; V is &#x2014;C(O)&#x2014;, &#x2014;S(O)&#x2014;, or &#x2014;S(O)&#x2014;; W is &#x2014;N(R)&#x2014;, &#x2014;O&#x2014;, or a bond (wherein Ris a hydrogen atom or a hydrocarbon group which may be substituted); X is alkylene which may be substituted; Y is &#x2014;C(O)&#x2014;, &#x2014;S(O)&#x2014;, or &#x2014;S(O)&#x2014;; Z is a bond, a chain hydrocarbon group which may be substituted, or &#x2014;N&#x2550;; ring A is a non-aromatic nitrogen-containing heterocyclic ring which may be substituted; ring B is a nitrogen-containing heterocyclic ring which may be substituted; and[Chemical formula 2],are each independently a single bond or a double bond; provided that Rmay be bonded to Rto form a non-aromatic nitrogen-containing heterocyclic ring and that Rmay be bonded to a substituent of X to form a non-aromatic nitrogen-containing heterocyclic ring which may be substituted.

Urea derivative, process for producing the same, and use

The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I): wherein Rrepresents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, Xrepresents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Yrepresents &#x2014;C(O)&#x2014;, &#x2014;S(O)&#x2014; or &#x2014;S(O)&#x2014;, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, Xrepresents a bond or an optionally substituted lower alkylene, Yrepresents &#x2014;C(O)&#x2014;, &#x2014;S(O)&#x2014;, &#x2014;S(O)&#x2014; or &#x2014;C(&#x2550;NR)&#x2014;, Xrepresents an optionally substituted Calkylene or an optionally substituted Calkenylene, Zrepresents &#x2014;N(R)&#x2014;, &#x2014;O&#x2014; or a bond, Zrepresents &#x2014;C(R)(R)&#x2014;, &#x2014;N(R)&#x2014;, etc., and Zrepresents &#x2014;C(R)(R)&#x2014;, &#x2014;N(R)&#x2014;, etc., or a salt thereof.

Growing community of inventors

Kanagawa, Japan

Yasuhiro Imaeda