Other

Fujifilm Corporation

Consejo Superior De Investigaciones Cientificas

Katholieke Universiteit Leuven

Yasuhiro Igarashi

Tamotsu Furumai

Yukio Sato

Toshikazu Oki

Jan Balzarini

Luis Miguel Ruiz Pérez

Tomio Nishimura

Hitoshi Kunoh

Masafumi Shimizu

Victor Castillo Acosta

Dolores González Pacanowska

Luis Miguel Ruiz PÉREZ

Víctor Castillo Acosta

Dolores GONZÁLEZ Pacanowska

The present invention relates to a class of novel pradimicins and analogues and derivatives thereof, including the compounds of formula A, I and 111, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof and their use to treat or prevent kinetoplastid infections and their use to manufacture a medicine to treat or prevent kinetoplastid infections, particularly infections withandsuch asand. wherein R, R, R, R, R, R, R, R, Rand Rare as defined in the claimor as described in detail in the description of the invention. The present invention also relates to pharmaceutical compositions of said compounds and the use of said pharmaceutical compositions to treat or prevent kinetoplastid infections. The present invention further relates active ingredients, more specifically as medicaments for the treatment of kinetoplastid infections and pathologic conditions such as, but not limited to Trypanosomiasis, such as African trypanosomiasis, sleeping sickness, Chagas disease and leishmaniasis. 

Pradimicin derivatives for the treatment of diseases caused by kinetoplastids

A dicarboxylic acid compound obtainable by oxidative degradation of pradimicin antibiotics, which are antibiotics consisting of the benzonaphthacene skeleton, a D-amino acid side chain and a sugar chain, for the second saccharide residue of the sugar chain, and use thereof utilizing a specific microorganism binding property thereof are provided. The dicarboxylic acid compound has significantly improved water-solubility compared with the raw material antibiotics, whist maintaining the specific microorganism binding property.

Benzonaphthacene glycoside derivative and use thereof

A disease control agent and a phytoalexin inducing agent, comprising Streptomyces sp. R-5 as an active ingredient are disclosed. Disease-resistant plants may be produced by inoculating plants with the disclosed Streptomyces sp. R-5. The disease control agent and a phytoalexin inducing agent are further useful in that they have low toxicity to humans and cause no environmental contamination.

Plant disease control agent

Growing community of inventors

Toyama, Japan

Yasuhiro Igarashi