Takeda Pharmaceutical Company Limited

Yasuhiro Hiraishi

Masami Kusaka

Muneo Nonomura

Masao Nagao

Yoshihiro Omachi

Shigehiro Asano

The present invention provides a microneedle patch which can solve the problem that microneedle production is difficult and requires high accuracy, the problem that time and mental burdens on a health professional and a patient are large, and the problem caused by compounding a plurality of drugs. The microneedle patch comprises a large number of drug-carrying microprojectionserected on one support sheet, each microprojectionhaving a drug layersoluble in vivo at its top part and having an intermediate layerunder the drug layer, the intermediate layercontaining a polymeric substance for adhesion of the drug layerto the support sheet, the drug layerat the top part of the microprojectioncontaining a single drug, the microprojectionsholding difference types of drugs being arranged together on the support sheet

Microneedle patch

The present invention provides a pharmaceutical composition or a solid preparation containing a stabilized pharmaceutically active ingredient and a stabilizing method thereof. According to the present invention, a pharmaceutical composition can be stabilized by containing a nonpeptidic pharmaceutically active ingredient having a primary or secondary amino group, an excipient and an acidic compound. In addition, a solid preparation containing a pharmaceutically active ingredient, titanium oxide, a plasticizer and a chain organic acid can enhance the stability of the pharmaceutically active ingredient during light irradiation.

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Osaka, Japan

Yasuhiro Hiraishi