Ube Industries, Inc.

Yasuhiro Aga

Tomio Kimura

Noriaki Iwase

Shigeyuki Kono

Sayaka Ogi

Shigeru Ushiyama

Hidetoshi Sunamoto

Yusuke Shiraishi

Masahiro Kojima

Satoshi Umezaki

Takashi Matsushita

Kazuhiro Onuma

Makoto Okudo

Masayuki Tanaka

Masahiko Hagihara

Yukinori Wada

Yasunori Tsuzaki

Masaaki Matoyama

Naoto Suzuki

Kimihiko Yoshimura

Hayato Nishiyama

Masao Maruyama

Nobuyoshi Fujii

Tohru Hasegawa

The present invention provides a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. [In the formula, the two Rs each independently represents a Calkyl group, or are bonded together to form a Calkylene group, A represents a Caryl group (which may be a substituted Caryl group), Z represents a hydrogen atom or a Calkyl group (which may be a substituted Caryl group), or A and Z may be bonded to each other, with the group represented by Z—N-A forming a bicyclic fused heteroaryl group, which may be substituted, and R, R, and Reach independently represents a linear or branched Calkyl group that may be substituted.]

Dihydropyrrolopyrazole derivative

A pharmaceutical composition including a compound represented by the formula (I) or a pharmacologically acceptable salt thereof wherein two R moieties each independently are a Calkyl group or are groups bonded to each other to form a Calkylene group; A is an optionally substituted Caryl group or an optionally substituted heteroaryl group; and R, Rand Reach independently are an optionally substituted linear or branched Calkyl group, wherein the pharmaceutical composition is administered in combination with an immunotherapeutic agent. 

Pharmaceutical composition administered in combination with substituted dihydropyrrolopyrazole compound and immunotherapeutic agent

The present invention provides a compound represented by the general formula (Ia) or a pharmacologically acceptable salt thereof. In the general formula (Ia), two R moieties each independently represent a Calkyl group or the like; and R, Rand Reach independently represent an optionally substituted linear or branched Calkyl group. 

Substituted dihydropyrrolopyrazole derivative

Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof: wherein Lis an optionally substituted Calkylene group or the like, Lis a single bond or the like, Lis a single bond or the like, R, R, and Rare each independently an optionally substituted Calkyl group or the like, Ris a hydrogen atom or the like, and Ris a hydrogen atom or the like.

Substituted dihydropyrrolopyrazole compound

The present invention relates to a benzazepinone compound represented by the following formula (I): wherein Rrepresents a C-Calkyl group or halogeno C-Calkyl group, Rrepresents a carboxyl group which may be protected, and Y represents a group represented by the formula (II): wherein Z represents CH or a nitrogen atom,or a pharmaceutically acceptable salt thereof.

Benzazepinone compound

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Ube, Japan

Yasuhiro Aga