Otsuka Pharmaceutical Company, Limited

Eiken Kagaku Kabushiki Kaisha

Yasuhiro Abiru

Takashi Hayashi

Masayuki Takahashi

Ikutaro Sato

Yoshikazu Shimada

Tadaaki Ohtani

Setsuko Yasuda

Norihiro Miyazawa

Shigeto Uchiyama

Tomomi Ueno

Megumi Kumemura

Yoshikazu Isono

Rieko Endo

Hisako Mori

Kumiko Shindome

Katsushi Abe

Yasutaka Ikeda

Tsubasa Mizokami

Hiroshi Okuma

Minoru Akiyama

Ayuko Oyama

Chieko Ando

Takayuki Minekawa

The present application provides a method for improvement in physical activity efficiency, a method for reducing fatigue, and a method for improving dynamic/kinetic visual acuity, comprising administering a composition comprising a kaempferol analog to a subject in need thereof.

Kaempferol analog-containing composition

An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.

Fermentation product containing equol-producing microorganism having maintained equol-producing ability, and method for producing same

The determination method of the present invention includes steps of measuring equol in a biological sample derived from a subject who has ingested soybean isoflavone by an immunological method using S-equol as at least one antigen selected from the group consisting of the standard antigen and the labeled antigen, and determining an equol-producing ability of the subject based on the measured value of equol obtained in the above step.

Method for measurement of equol in biological sample by immunoassay, kit for the measurement, and method for determination of equol production ability of subject

An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and genes. The present invention provides a dihydrodaidzein synthesizing enzyme, tetrahydrodaidzein synthesizing enzyme, equol synthesizing enzyme, and genes coding these enzymes. The present invention also provides a process for synthesizing dihydrodaidzein, tetrahydrodaidzein, and/or equol using these enzymes.

Enzyme associated with equol synthesis

Growing community of inventors

Osaka, Japan

Yasuhiro Abiru