Sumitomo Chemical Company, Limited

Yasuhiko Takahashi

Kenji Oeda

Yasuo Matsumoto

Tomoyuki Takaku

Provided is an insect odorant receptor co-receptor that exhibits excellent detection sensitivity to an odorous substance when bound to an odorant receptor to form an odorant receptor complex. The odorant receptor co-receptor includes a first amino acid sequence and a second amino acid sequence subsequently to the farthest carboxyl-terminal amino acid residue of the first amino acid sequence.

Odorant receptor co-receptor

The present invention relates to a method for improving symptom of mood disorder or its related disorder comprising a step of allowing Gm1 protein and the like to be excessively present in a brain of a mammal, and a non-human mammal, to which the method has been applied, and the like.

Method of ameliorating symptom caused by mood disturbance

A novel protein (Gm1) includes an amino acid sequence part having a high homology with a domain having a high homology with a GTP binding site and a GTPase site conserved among G protein &#x3b1; subunits and a trimer forming domain conserved among G protein &#x3b1; subunits. The Gm1 protein is involved in signal transduction via a G protein-coupled receptor (GPCR) stimulation. The Gm1 protein is expressed intensively in human brain, thymus, testes, spleen, small intestine, uterus and heart. A method for screening for a substance capable of regulating a cellular signal transduction employs a polynucleotide encoding the Gm1 protein.

Protein involved in G protein-coupled receptor mediated signal transduction with ability to mediate signal transduction from a dopamine D1 receptor or an adenosine A2A receptor to an adenylate cyclase and utilization thereof

We identified a novel protein (Gm1) comprising an amino acid sequence part having a high homology with a domain having a high homology with a GTP binding site and a GTPase site conserved among G protein &#x3b1; subunits and a trimer forming domain conserved among G protein &#x3b1; subunits. The Gm1 is involved in an signal transduction via a G protein-coupled receptor (GPCR) stimulation. Accordingly, this protein is considered to be a novel G protein. The Gm1 is expressed intensively in human brain, thymus, testes, spleen, small intestine, uterus and heart. We also established a method for screening for a substance capable of regulating a cellular signal transduction employing a polynucleotide encoding the Gm1.

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Toyonaka, Japan

Yasuhiko Takahashi