Nippon Shoji Kabushiki Kaisha

Azwell Inc.

Yasuhiko Sakamoto

Kenichi Kashima

Shigetaka Takemura

Masakatu Hisaki

Yoichiro Ohta

Hiroichi Nagai

Kenji Kawanishi

Masakazu Hojo

Takeshi Takeno

Takushi Kurihara

Toshimi Sakurai

Kayo Yokode

Osamu Katayama

Yasuko Takemura

Hirohiko Sakamoto

Yoshinobu Akimoto

Shinya Harusawa

Hiroyoshi Hata

An improvement in the production of imidazole derivatives including histamine Hagonist immepip and histamine Hantagonist VUF4929. Desired imidazole derivatives can be easily obtained in high yield by using novel intermediates represented by the general formula (I): (I) wherein Ris an amino-protecting group; Rand Rare each independently hydrogen, lower alkyl, or hydroxylated lower alkyl; Ris lower alkyl, halogenated lower alkyl, or substituted or unsubstituted phenyl; and A is Calkylene

Production of imidazole derivatives and novel intermediates of the derivatives

A process for advantageously preparing a piperazinesulfonamide derivative represented by the general formula (III):

Process for producing piperazinesulfonamide derivatives and salts thereof

Diazacycloalkanealkylsulfonamide derivatives

Novel 3-aminocarbonyl-1,4-dihydropyridine-5-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is H, C.sub.1-5 alkyl, C.sub.2-5 alkenyl, C.sub.3.5 alkynyl, C.sub.3-8 cycloalkyl, R.sup.2 is C.sub.1-10 alkyl, and the NO.sub.2 group is substituted at ortho- or meta-position, provided that when the NO.sub.2 group is substituted at ortho-position and R.sup.2 is methyl, R.sup.1 is C.sub.3-5 alkyl, C.sub.2-5 alkenyl, C.sub.3-5 alkynyl, or C.sub.3-8 cycloalkyl, and when the NO.sub.2 group is substituted at meta-position and R.sup.1 is H, R.sup.2 is C.sub.3-10 alkyl, which have excellent hypotensive, vasodilating activities and are useful for the prophylaxis and treatment of hypertension, ischemic heart diseases and cerebral and peripheral circulation diseases.

3-Aminocarbonyl-1,4-dihydropyridine-5-carboxylic acid compounds, and

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Habikino, Japan

Yasuhiko Sakamoto