Tanabe Seiyaku Company, Limited

Other

Yasuhiko Ozaki

Kimiaki Hayashi

Ichizo Inoue

Kenji Yamada

Hideyuki Takenaga

Ryuzo Yoshioka

Takeji Shibatani

Hiroshi Fujiwara

Shinji Takamura

Hiroaki Matsumae

Jun-ichiro Kita

Hiroyasu Seko

Shin-ichi Yamada

Shinichi Yamada

Takuo Nishida

Akiko Idei

The present invention is to provide a benzenesulfonic acid salt and a benzoic acid salt of (S)-4-&lsqb;4-&lsqb;(4-chlorophenyl) (2-pyridyl)methoxy&rsqb;piperidino&rsqb;butanoic acid represented by the formula (I):

Acid-addition salts of optically active piperidine compound and process for producing the same

Process for preparing optically active trans-3-phenylglycidamide compound, which comprises subjecting racemic trans-3-phenylglycidamide compound of the formula (I) ##STR1## wherein Ring A is substituted or unsubstituted benzene, and R.sup.1 is H or lower alkyl, to optical resolution using a microorganism having ability of preferentially hydrolyzing one of (2S,3R) isomer or (2R,3S) isomer thereof, and process for preparing an optically active 1,5-benzothiazepine derivative from the thus-obtained optically active trans-3-phenylglycidamide compound.

Process for preparing optically active trans-3-phenylglycidamide

Process for preparing optically active cis-3-hydroxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one compounds [I] of the formula: ##STR1## wherein Ring A and Ring B are substituted or unsubstituted benzene, R.sup.1 is hydrogen or di-lower alkylaminoalkyl, which comprises subjecting 1,5-benzothiazepin-4(5H)-one (II) of the formula [II]: ##STR2## wherein R.sup.4 is hydrogen or lower alkanoyl, and the other symbols are the same as defined above, to asymmetric reduction with a reaction product of optically active .alpha.-amino acid and metal hydride, in high optically yield, and said compounds [I] are very important as intermediate for preparing various medicines.

Process for preparing optically active benzothiazepine compounds by

A thiophene derivative of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are a lower alkyl group, Ring A is a substituted or unsubstituted phenyl group and p is an integer of 1 to 3, or a salt thereof and processes for preparing the same are disclosed. The thiophene derivative (I) is useful as the regulator of gastrointestinal tract motility.

Thiophene derivative and process for preparing the same

A thiophen derivative of the formula: ##STR1## wherein R.sup.1, and R.sup.2 and R.sup.3 are a lower alkyl group, Ring A is phenyl, a lower alkylenedioxy-substituted phenyl, a phenyl group having 1 to 3 substituent(s) selected from the group consisting of a lower alkyl group, a lower alkylthio group, a lower alkoxy group, a phenyl-lower alkoxy group, a lower alkoxycarbonyl group, a halogen atom, amino group and hydroxy group, X is --OCO--, --O-- or --S--, m and n are an integer of zero or 1, and p and q are an integer of zero, 1 or 2, or a salt thereof.

Growing community of inventors

Osaka, Japan

Yasuhiko Ozaki