Shionogi & Company Limited

The University of Tokyo

Tohoku University

Shionogi Company Limited

Yasuhiko Kanda

Akira Kato

Shinji Suzuki

Kazuo Ueda

Akira Yukimasa

Akihiro Hori

Naotake Kobayashi

Naohiro Itoh

Gaku Sakaguchi

Hidekazu Haraguchi

Ken Yasui

Yuji Koriyama

Tetsuo Nagano

Toshio Fujishita

Nobuyuki Tanaka

Takashi Kawasuji

Hirotatsu Kojima

Osamu Nureki

Yukio Tada

Hiroshi Nishimasu

Shiro Kida

Masahiro Fuji

Shozo Takechi

Yuuji Kooriyama

Takayoshi Okabe

Ryuichiro Ishitani

Yusuke Tateno

Junken Aoki

Junji Yamane

Mitsuyasu Kawaguchi

Yoshiyuki Kioi

Ryuichi Kiyama

A compound according to any one of formula (Ia) to (Ic), or its pharmaceutically acceptable salt: 

Pyrimidinone derivative having autotaxin-inhibitory activity

The present invention provides an integrase inhibitor. The inventors have found the following compound of formula (I) possessing an integrase inhibitory activity.  

Antiviral agent

A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): 

Aminodihydrothiazine derivatives

A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I): 

Pharmaceutical composition for treating alzheimer's disease

A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): 

A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted heterocyclic group;E is lower alkylene;X is S;Ris a hydrogen atom or lower alkyl;R, R, R, R, Rand Ris each independently a hydrogen atom, halogen, or hydroxy etc.;n and m are each independently an integer of 0 to 3;n+m is an integer of 0 to 3;Ris a hydrogen atom or substituted lower alkyl;or its pharmaceutically acceptable salt thereof.

A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group;

Arylacetate derivatives having isoxazole skeleton

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Osaka, Japan

Yasuhiko Kanda