Chugai Seiyaku Kabushiki Kaisha

Yasuharu Kato

Kazutomo Kinoshita

Hiroshi Sakamoto

Takashi Emura

Yoshiyuki Ono

Nobuhiro Oikawa

Hatsuo Kawada

Nobuya Ishii

Toshiya Ito

Kenji Morikami

Noriyuki Furuichi

MinJeong Park

WooSang Hong

Kohsuke Asoh

Akira Kawase

Tsuyoshi Haneishi

Noriaki Maruyama

Takuma Ikeda

Yasushi Kitoh

Mio Kobayashi

A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: 

Tetracyclic compound

There are provided a novel process for producing [{(5Z,7E)-(1S,3R,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(19),16-tetraen-20-yl}oxy]-N-(2,2,3,3,3-pentafluoropropyl)acetamide, which process is characterized by irradiating a compound represented by the formula: with UV to ring-open the compound, and then isomerizing the resulting compound; an intermediate useful for carrying out the process; and a process for producing the intermediate.

Process for producing vitamin D derivative using photoreaction

Growing community of inventors

Shizuoka, Japan

Yasuharu Kato