Zymogenetics, Inc.

Yasmin A Chandrasekher

Wenfeng Xu

Wayne R Kindsvogel

Stacey R Dillon

Anthony W Siadak

Margaret Dow Moore

Steven D Hughes

Joyce M Lehner

Pallavur V Sivakumar

Penny Thompson

Hal Blumberg

Julia E Novak

Patricia A McKernan

Donald C Foster

Stephen R Jaspers

Zhi Chen

Cindy A Sprecher

James D Kelly

Karen L Madden

Pallavar V Sivakumar

Patricia A Mckernan

Maribeth A Eagan

Xu Wenfeng

Maribeth A Eagen

The present invention relates to blocking the activity of IL-20 polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.

Anti-IL-20 antibodies and binding partners and methods of using in inflammation

The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.

Anti-IL-TIF antibodies

A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.

Method of treating rheumatoid arthritis using anti-IL-20 antibodies

Methods of treatment using anti-IL-20 antibodies

The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.

Methods of producing anti-IL-22RA antibodies

Use of Interleukin-20 for treating cervical cancer or cells infected with human papilloma virus. IL-20 can be administered alone or in conjunction with radiation or chemotherapeutic agents or surgical excision of the involved cells or lesions.

Method for treating cervical cancer

Anti-IL-22RA antibodies and binding partners and methods of using in inflammation

The present invention provides methods of treating psoriasis in a subject (i.e., psoriasis associated with a joint disease), by administering to the subject an effective dose of a composition comprising a soluble IL-22R/IL-20RB heterodimeric polypeptide, wherein the heterodimeric polypeptide comprises an IL-22R extracellular domain covalently linked to an IL-20RB extracellular domain.

Soluble heterodimeric cytokine receptor

Methods of treatment using anti-IL-22RA antibodies

Method for treating inflammation

A method for treating down-regulating IL-19 or mda7 by administering the soluble IL-20RA/IL-20R heterodimeric receptor.

Anti-IL-TIF antibodies and methods of using in inflammation

A soluble receptor that binds to IL-20 having two polypeptide subunits, IL-22R and IL-20RB. The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

Methods of using soluble heterodimeric cytokine receptor

Growing community of inventors

Mercer Island, WA, United States of America

Yasmin A Chandrasekher