Corixa Corporation

Glaxosmithkline Biologicals Sa

Yasir A Skeiky

Steven G Reed

Mark R Alderson

Antonio Campos-Neto

Davin C Dillon

Michael J Lodes

Raymond L Houghton

Jeff Guderian

Shyian Jen

Pamela Ovendale

Patricia Dianne McNeill

Peter Probst

Ajay Bhatia

John R Webb

Thomas S Vedvick

Daniel R Twardzik

Rhea N Coler

Martine Marchand

Yves Lobet

Pascal Mettens

Jean-Francois Lucien Maisonneuve

Antonio Campos-Nero

Jeffrey Guderian

Brenda Maisonneuve

Florence Bernadette Nozay

The present invention relates to compositions comprising proteins or polynucleotides ofsp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis ofinfection.

Vaccines against chlamydial infection

The present invention relates to fusion proteins containing at least twoantigens. In particular, it relates to bi-fusion proteins which contain two individualantigens, tri-fusion proteins which contain threeantigens, tetra-fusion proteins which contain fourantigens, and penta-fusion proteins which contain fiveantigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.

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The present invention relates to compositions and fusion proteins containing at least twosp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.

Fusion proteins of mycobacterium tuberculosis

The present invention relates to fusion proteins containing at least twospecies antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individualantigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.

Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or moreproteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection ofinfection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization againstinfection.

Compounds and methods for diagnosis and immunotherapy of tuberculosis

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Bellevue, WA, United States of America

Yasir A Skeiky